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Defining multiple joint osteoarthritis, its frequency and impact in a community-based cohort.

Publication ,  Journal Article
Gullo, TR; Golightly, YM; Cleveland, RJ; Renner, JB; Callahan, LF; Jordan, JM; Kraus, VB; Nelson, AE
Published in: Semin Arthritis Rheum
June 2019

BACKGROUND/PURPOSE: To update definitions of multiple joint osteoarthritis (MJOA), and to determine the frequency and impact of MJOA in a community-based cohort. METHODS: Following PRISMA guidelines and with the help of a professional research librarian, we performed a systematic review in Medline using the terms osteoarthritis, generalized, polyarticular, multiple joint, and multi-joint among others, to obtain articles related to MJOA. A total of 42 articles were included for data extraction based on multiple criteria including the requirement for a clearly stated definition of OA assessed at more than one body site. We assessed frequency of these definitions in the Johnston County OA Project (JoCo OA) cohort as well as outcomes related to general health and physical function. RESULTS: A total of 6 clearly stated definitions for MJOA were identified. These definitions were integrated with a list of 24 definitions from our previous systematic review and distilled down to produce 10 literature-derived, operationalized MJOA definitions. Based on these definitions, high frequencies of radiographic (4-74%) and symptomatic (2-52%) MJOA were found in the JoCo OA. Significant detrimental effects were seen on general health and physical function for most definitions. CONCLUSIONS: We constructed a list of 10 summary MJOA definitions based in the literature that are frequent and associated with important clinical outcomes. These definitions capture some of the variability of MJOA phenotypes and provide a starting point for future analyses of both existing and newly initiated studies.

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Published In

Semin Arthritis Rheum

DOI

EISSN

1532-866X

Publication Date

June 2019

Volume

48

Issue

6

Start / End Page

950 / 957

Location

United States

Related Subject Headings

  • Radiography
  • Prevalence
  • Osteoarthritis
  • Knee Joint
  • Humans
  • Hip Joint
  • Health Status
  • Hand Joints
  • Arthritis & Rheumatology
  • 3202 Clinical sciences
 

Citation

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Gullo, T. R., Golightly, Y. M., Cleveland, R. J., Renner, J. B., Callahan, L. F., Jordan, J. M., … Nelson, A. E. (2019). Defining multiple joint osteoarthritis, its frequency and impact in a community-based cohort. Semin Arthritis Rheum, 48(6), 950–957. https://doi.org/10.1016/j.semarthrit.2018.10.001
Gullo, Terese R., Yvonne M. Golightly, Rebecca J. Cleveland, Jordan B. Renner, Leigh F. Callahan, Joanne M. Jordan, Virginia B. Kraus, and Amanda E. Nelson. “Defining multiple joint osteoarthritis, its frequency and impact in a community-based cohort.Semin Arthritis Rheum 48, no. 6 (June 2019): 950–57. https://doi.org/10.1016/j.semarthrit.2018.10.001.
Gullo TR, Golightly YM, Cleveland RJ, Renner JB, Callahan LF, Jordan JM, et al. Defining multiple joint osteoarthritis, its frequency and impact in a community-based cohort. Semin Arthritis Rheum. 2019 Jun;48(6):950–7.
Gullo, Terese R., et al. “Defining multiple joint osteoarthritis, its frequency and impact in a community-based cohort.Semin Arthritis Rheum, vol. 48, no. 6, June 2019, pp. 950–57. Pubmed, doi:10.1016/j.semarthrit.2018.10.001.
Gullo TR, Golightly YM, Cleveland RJ, Renner JB, Callahan LF, Jordan JM, Kraus VB, Nelson AE. Defining multiple joint osteoarthritis, its frequency and impact in a community-based cohort. Semin Arthritis Rheum. 2019 Jun;48(6):950–957.
Journal cover image

Published In

Semin Arthritis Rheum

DOI

EISSN

1532-866X

Publication Date

June 2019

Volume

48

Issue

6

Start / End Page

950 / 957

Location

United States

Related Subject Headings

  • Radiography
  • Prevalence
  • Osteoarthritis
  • Knee Joint
  • Humans
  • Hip Joint
  • Health Status
  • Hand Joints
  • Arthritis & Rheumatology
  • 3202 Clinical sciences