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Neurogenesis in the sea urchin embryo is initiated uniquely in three domains.

Publication ,  Journal Article
McClay, DR; Miranda, E; Feinberg, SL
Published in: Development (Cambridge, England)
November 2018

Many marine larvae begin feeding within a day of fertilization, thus requiring rapid development of a nervous system to coordinate feeding activities. Here, we examine the patterning and specification of early neurogenesis in sea urchin embryos. Lineage analysis indicates that neurons arise locally in three regions of the embryo. Perturbation analyses showed that when patterning is disrupted, neurogenesis in the three regions is differentially affected, indicating distinct patterning requirements for each neural domain. Six transcription factors that function during proneural specification were identified and studied in detail. Perturbations of these proneural transcription factors showed that specification occurs differently in each neural domain prior to the Delta-Notch restriction signal. Though gene regulatory network state changes beyond the proneural restriction are largely unresolved, the data here show that the three neural regions already differ from each other significantly early in specification. Future studies that define the larval nervous system in the sea urchin must therefore separately characterize the three populations of neurons that enable the larva to feed, to navigate, and to move food particles through the gut.

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Published In

Development (Cambridge, England)

DOI

EISSN

1477-9129

ISSN

0950-1991

Publication Date

November 2018

Volume

145

Issue

21

Start / End Page

dev167742

Related Subject Headings

  • Transcription Factors
  • Signal Transduction
  • Nodal Protein
  • Neurogenesis
  • Models, Biological
  • Lytechinus
  • Gene Regulatory Networks
  • Gene Expression Regulation, Developmental
  • Fibroblast Growth Factors
  • Embryo, Nonmammalian
 

Citation

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McClay, D. R., Miranda, E., & Feinberg, S. L. (2018). Neurogenesis in the sea urchin embryo is initiated uniquely in three domains. Development (Cambridge, England), 145(21), dev167742. https://doi.org/10.1242/dev.167742
McClay, David R., Esther Miranda, and Stacy L. Feinberg. “Neurogenesis in the sea urchin embryo is initiated uniquely in three domains.Development (Cambridge, England) 145, no. 21 (November 2018): dev167742. https://doi.org/10.1242/dev.167742.
McClay DR, Miranda E, Feinberg SL. Neurogenesis in the sea urchin embryo is initiated uniquely in three domains. Development (Cambridge, England). 2018 Nov;145(21):dev167742.
McClay, David R., et al. “Neurogenesis in the sea urchin embryo is initiated uniquely in three domains.Development (Cambridge, England), vol. 145, no. 21, Nov. 2018, p. dev167742. Epmc, doi:10.1242/dev.167742.
McClay DR, Miranda E, Feinberg SL. Neurogenesis in the sea urchin embryo is initiated uniquely in three domains. Development (Cambridge, England). 2018 Nov;145(21):dev167742.
Journal cover image

Published In

Development (Cambridge, England)

DOI

EISSN

1477-9129

ISSN

0950-1991

Publication Date

November 2018

Volume

145

Issue

21

Start / End Page

dev167742

Related Subject Headings

  • Transcription Factors
  • Signal Transduction
  • Nodal Protein
  • Neurogenesis
  • Models, Biological
  • Lytechinus
  • Gene Regulatory Networks
  • Gene Expression Regulation, Developmental
  • Fibroblast Growth Factors
  • Embryo, Nonmammalian