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Development and Validation of a High-Quality Composite Real-World Mortality Endpoint.

Publication ,  Journal Article
Curtis, MD; Griffith, SD; Tucker, M; Taylor, MD; Capra, WB; Carrigan, G; Holzman, B; Torres, AZ; You, P; Arnieri, B; Abernethy, AP
Published in: Health services research
December 2018

To create a high-quality electronic health record (EHR)-derived mortality dataset for retrospective and prospective real-world evidence generation.Oncology EHR data, supplemented with external commercial and US Social Security Death Index data, benchmarked to the National Death Index (NDI).We developed a recent, linkable, high-quality mortality variable amalgamated from multiple data sources to supplement EHR data, benchmarked against the highest completeness U.S. mortality data, the NDI. Data quality of the mortality variable version 2.0 is reported here.For advanced non-small-cell lung cancer, sensitivity of mortality information improved from 66 percent in EHR structured data to 91 percent in the composite dataset, with high date agreement compared to the NDI. For advanced melanoma, metastatic colorectal cancer, and metastatic breast cancer, sensitivity of the final variable was 85 to 88 percent. Kaplan-Meier survival analyses showed that improving mortality data completeness minimized overestimation of survival relative to NDI-based estimates.For EHR-derived data to yield reliable real-world evidence, it needs to be of known and sufficiently high quality. Considering the impact of mortality data completeness on survival endpoints, we highlight the importance of data quality assessment and advocate benchmarking to the NDI.

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Published In

Health services research

DOI

EISSN

1475-6773

ISSN

0017-9124

Publication Date

December 2018

Volume

53

Issue

6

Start / End Page

4460 / 4476

Related Subject Headings

  • United States
  • Neoplasms
  • Mortality
  • Medical Oncology
  • Humans
  • Health Policy & Services
  • Electronic Health Records
  • Databases, Factual
  • Data Accuracy
  • 4407 Policy and administration
 

Citation

APA
Chicago
ICMJE
MLA
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Curtis, M. D., Griffith, S. D., Tucker, M., Taylor, M. D., Capra, W. B., Carrigan, G., … Abernethy, A. P. (2018). Development and Validation of a High-Quality Composite Real-World Mortality Endpoint. Health Services Research, 53(6), 4460–4476. https://doi.org/10.1111/1475-6773.12872
Curtis, Melissa D., Sandra D. Griffith, Melisa Tucker, Michael D. Taylor, William B. Capra, Gillis Carrigan, Ben Holzman, et al. “Development and Validation of a High-Quality Composite Real-World Mortality Endpoint.Health Services Research 53, no. 6 (December 2018): 4460–76. https://doi.org/10.1111/1475-6773.12872.
Curtis MD, Griffith SD, Tucker M, Taylor MD, Capra WB, Carrigan G, et al. Development and Validation of a High-Quality Composite Real-World Mortality Endpoint. Health services research. 2018 Dec;53(6):4460–76.
Curtis, Melissa D., et al. “Development and Validation of a High-Quality Composite Real-World Mortality Endpoint.Health Services Research, vol. 53, no. 6, Dec. 2018, pp. 4460–76. Epmc, doi:10.1111/1475-6773.12872.
Curtis MD, Griffith SD, Tucker M, Taylor MD, Capra WB, Carrigan G, Holzman B, Torres AZ, You P, Arnieri B, Abernethy AP. Development and Validation of a High-Quality Composite Real-World Mortality Endpoint. Health services research. 2018 Dec;53(6):4460–4476.
Journal cover image

Published In

Health services research

DOI

EISSN

1475-6773

ISSN

0017-9124

Publication Date

December 2018

Volume

53

Issue

6

Start / End Page

4460 / 4476

Related Subject Headings

  • United States
  • Neoplasms
  • Mortality
  • Medical Oncology
  • Humans
  • Health Policy & Services
  • Electronic Health Records
  • Databases, Factual
  • Data Accuracy
  • 4407 Policy and administration