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Agreement of an echocardiogram-based diagnosis of pulmonary hypertension in infants at risk for bronchopulmonary dysplasia among masked reviewers.

Publication ,  Journal Article
McCrary, AW; Barker, PCA; Torok, RD; Spears, TG; Li, JS; Hornik, CP; Laughon, MM
Published in: J Perinatol
February 2019

OBJECTIVE: To evaluate the agreement of an echocardiogram-based pulmonary hypertension diagnosis in premature infants at risk for bronchopulmonary dysplasia (BPD). STUDY DESIGN: Echocardiograms from infants born ≤28 weeks post menstrual age were retrospectively reviewed with a standardized reading protocol by three pediatric cardiologists masked to patient's clinical history to determine the presence of pulmonary hypertension. RESULTS: A total of 483 echocardiograms from 49 unique patients were each reviewed by three pediatric cardiologists. Overall there was an 82.9% agreement on the presence of pulmonary hypertension among the three readers (95% CI: 78.4%, 85.4%) with a modified Fleiss' kappa of 0.759 (95% CI: 0.711, 0.801). Percent agreement between rereads was 92.4%, and modified Fleiss' kappa was 0.847 (95% CI: 0.750, 0.931). CONCLUSIONS: Using a standardized reading protocol and echocardiogram-based definition of pulmonary hypertension, there is high inter- and intra-rater agreement for the diagnosis of pulmonary hypertension in at-risk premature infants, suggesting echocardiography can be successfully used for clinical and research monitoring of pulmonary hypertension in infants.

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Published In

J Perinatol

DOI

EISSN

1476-5543

Publication Date

February 2019

Volume

39

Issue

2

Start / End Page

248 / 255

Location

United States

Related Subject Headings

  • Severity of Illness Index
  • Risk Factors
  • Retrospective Studies
  • Pediatrics
  • Male
  • Logistic Models
  • Infant, Premature
  • Infant, Newborn
  • Infant
  • Hypertension, Pulmonary
 

Citation

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McCrary, A. W., Barker, P. C. A., Torok, R. D., Spears, T. G., Li, J. S., Hornik, C. P., & Laughon, M. M. (2019). Agreement of an echocardiogram-based diagnosis of pulmonary hypertension in infants at risk for bronchopulmonary dysplasia among masked reviewers. J Perinatol, 39(2), 248–255. https://doi.org/10.1038/s41372-018-0277-6
McCrary, Andrew W., Piers C. A. Barker, Rachel D. Torok, Tracy G. Spears, Jennifer S. Li, Christoph P. Hornik, and Matthew M. Laughon. “Agreement of an echocardiogram-based diagnosis of pulmonary hypertension in infants at risk for bronchopulmonary dysplasia among masked reviewers.J Perinatol 39, no. 2 (February 2019): 248–55. https://doi.org/10.1038/s41372-018-0277-6.
McCrary AW, Barker PCA, Torok RD, Spears TG, Li JS, Hornik CP, et al. Agreement of an echocardiogram-based diagnosis of pulmonary hypertension in infants at risk for bronchopulmonary dysplasia among masked reviewers. J Perinatol. 2019 Feb;39(2):248–55.
McCrary, Andrew W., et al. “Agreement of an echocardiogram-based diagnosis of pulmonary hypertension in infants at risk for bronchopulmonary dysplasia among masked reviewers.J Perinatol, vol. 39, no. 2, Feb. 2019, pp. 248–55. Pubmed, doi:10.1038/s41372-018-0277-6.
McCrary AW, Barker PCA, Torok RD, Spears TG, Li JS, Hornik CP, Laughon MM. Agreement of an echocardiogram-based diagnosis of pulmonary hypertension in infants at risk for bronchopulmonary dysplasia among masked reviewers. J Perinatol. 2019 Feb;39(2):248–255.

Published In

J Perinatol

DOI

EISSN

1476-5543

Publication Date

February 2019

Volume

39

Issue

2

Start / End Page

248 / 255

Location

United States

Related Subject Headings

  • Severity of Illness Index
  • Risk Factors
  • Retrospective Studies
  • Pediatrics
  • Male
  • Logistic Models
  • Infant, Premature
  • Infant, Newborn
  • Infant
  • Hypertension, Pulmonary