ATAC-ing the mechanisms of renin regulation.
Publication
, Journal Article
Crowley, SD
Published in: J Clin Invest
November 1, 2018
Renin-expressing cells have been conserved through evolution and maintain blood pressure and fluid homeostasis. Lack of availability of tools to study the specifics of renin regulation has limited advances in this field. In the current issue of the Journal of Clinical Investigation, Martinez and colleagues used the genome-wide assessment of the chromatin status of cells and uncovered a unique set of super-enhancers that determine the identity of renin cells. The renin super-enhancers play a key role in the molecular memory of renin cell function, a mechanism at the core of preserving homeostasis.
Duke Scholars
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Published In
J Clin Invest
DOI
EISSN
1558-8238
Publication Date
November 1, 2018
Volume
128
Issue
11
Start / End Page
4748 / 4750
Location
United States
Related Subject Headings
- Renin
- Regulatory Sequences, Nucleic Acid
- Immunology
- Homeostasis
- Genome
- Chromatin
- 42 Health sciences
- 32 Biomedical and clinical sciences
- 31 Biological sciences
- 11 Medical and Health Sciences
Citation
APA
Chicago
ICMJE
MLA
NLM
Crowley, S. D. (2018). ATAC-ing the mechanisms of renin regulation. J Clin Invest, 128(11), 4748–4750. https://doi.org/10.1172/JCI124177
Crowley, Steven D. “ATAC-ing the mechanisms of renin regulation.” J Clin Invest 128, no. 11 (November 1, 2018): 4748–50. https://doi.org/10.1172/JCI124177.
Crowley SD. ATAC-ing the mechanisms of renin regulation. J Clin Invest. 2018 Nov 1;128(11):4748–50.
Crowley, Steven D. “ATAC-ing the mechanisms of renin regulation.” J Clin Invest, vol. 128, no. 11, Nov. 2018, pp. 4748–50. Pubmed, doi:10.1172/JCI124177.
Crowley SD. ATAC-ing the mechanisms of renin regulation. J Clin Invest. 2018 Nov 1;128(11):4748–4750.
Published In
J Clin Invest
DOI
EISSN
1558-8238
Publication Date
November 1, 2018
Volume
128
Issue
11
Start / End Page
4748 / 4750
Location
United States
Related Subject Headings
- Renin
- Regulatory Sequences, Nucleic Acid
- Immunology
- Homeostasis
- Genome
- Chromatin
- 42 Health sciences
- 32 Biomedical and clinical sciences
- 31 Biological sciences
- 11 Medical and Health Sciences