Skip to main content

A Modular Implant System for Multimodal Recording and Manipulation of the Primate Brain.

Publication ,  Journal Article
Kleinbart, JE; Orsborn, AL; Choi, JS; Wang, C; Qiao, S; Viventi, J; Pesaran, B
Published in: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
July 2018

Neural circuitry can be investigated and manipulated using a variety of techniques, including electrical and optical recording and stimulation. At present, most neural interfaces are designed to accommodate a single mode of neural recording and/or manipulation, which limits the amount of data that can be extracted from a single population of neurons. To overcome these technical limitations, we developed a chronic, multi-scale, multi-modal chamber-based neural implant for use in non-human primates that accommodates electrophysiological recording and stimulation, optical manipulation, and wide-field imaging. We present key design features of the system and mechanical validation. We also present sample data from two non-human primate subjects to validate the efficacy of the design in vivo.

Duke Scholars

Published In

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

DOI

EISSN

2694-0604

ISSN

2375-7477

Publication Date

July 2018

Volume

2018

Start / End Page

3362 / 3365

Related Subject Headings

  • Primates
  • Neurons
  • Electrophysiological Phenomena
  • Brain
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kleinbart, J. E., Orsborn, A. L., Choi, J. S., Wang, C., Qiao, S., Viventi, J., & Pesaran, B. (2018). A Modular Implant System for Multimodal Recording and Manipulation of the Primate Brain. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2018, 3362–3365. https://doi.org/10.1109/embc.2018.8512993
Kleinbart, Jessica E., Amy L. Orsborn, John S. Choi, Charles Wang, Shaoyu Qiao, Jonathan Viventi, and Bijan Pesaran. “A Modular Implant System for Multimodal Recording and Manipulation of the Primate Brain.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference 2018 (July 2018): 3362–65. https://doi.org/10.1109/embc.2018.8512993.
Kleinbart JE, Orsborn AL, Choi JS, Wang C, Qiao S, Viventi J, et al. A Modular Implant System for Multimodal Recording and Manipulation of the Primate Brain. Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Annual International Conference. 2018 Jul;2018:3362–5.
Kleinbart, Jessica E., et al. “A Modular Implant System for Multimodal Recording and Manipulation of the Primate Brain.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, vol. 2018, July 2018, pp. 3362–65. Epmc, doi:10.1109/embc.2018.8512993.
Kleinbart JE, Orsborn AL, Choi JS, Wang C, Qiao S, Viventi J, Pesaran B. A Modular Implant System for Multimodal Recording and Manipulation of the Primate Brain. Annual International Conference of the IEEE Engineering in Medicine and Biology Society IEEE Engineering in Medicine and Biology Society Annual International Conference. 2018 Jul;2018:3362–3365.

Published In

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

DOI

EISSN

2694-0604

ISSN

2375-7477

Publication Date

July 2018

Volume

2018

Start / End Page

3362 / 3365

Related Subject Headings

  • Primates
  • Neurons
  • Electrophysiological Phenomena
  • Brain
  • Animals