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Predictors of Longitudinal Quality of Life in Juvenile Localized Scleroderma.

Publication ,  Journal Article
Ardalan, K; Zigler, CK; Torok, KS
Published in: Arthritis Care Res (Hoboken)
July 2017

OBJECTIVE: Localized scleroderma can negatively affect children's quality of life (QoL), but predictors of impact have not been well described. We sought to identify predictors of QoL impact in juvenile localized scleroderma patients. METHODS: We analyzed longitudinal data from a single-center cohort of juvenile localized scleroderma patients, using hierarchical generalized linear modeling (HGLM) to identify predictors of QoL impact. HGLM is useful for nested data and allows for evaluation of both time-variant and time-invariant predictors. RESULTS: The number of extracutaneous manifestations (ECMs; e.g., joint contracture and hemifacial atrophy) and female sex predicted negative QoL impact, defined as a Children's Dermatology Life Quality Index score >1 (P = 0.019 for ECMs and P = 0.002 for female sex). As the time since the initial visit increased, the odds of reporting a negative QoL impact decreased (P < 0.001). CONCLUSION: Our results suggest that ECMs, sex, and time since initial visit are more predictive of QoL impact in localized scleroderma than cutaneous features. Further study is required to determine which ECMs have the most impact on QoL, which factors underlie sex differences in QoL in localized scleroderma, and why increasing the time since the initial visit appears to be protective. An improved understanding of predictors of QoL impact may allow for the identification of patients at risk of poorer outcomes and for the tailoring of treatment and psychosocial support.

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Published In

Arthritis Care Res (Hoboken)

DOI

EISSN

2151-4658

Publication Date

July 2017

Volume

69

Issue

7

Start / End Page

1082 / 1087

Location

United States

Related Subject Headings

  • Scleroderma, Localized
  • Quality of Life
  • Predictive Value of Tests
  • Male
  • Longitudinal Studies
  • Humans
  • Female
  • Cohort Studies
  • Child
  • Adolescent
 

Citation

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Ardalan, K., Zigler, C. K., & Torok, K. S. (2017). Predictors of Longitudinal Quality of Life in Juvenile Localized Scleroderma. Arthritis Care Res (Hoboken), 69(7), 1082–1087. https://doi.org/10.1002/acr.23101
Ardalan, Kaveh, Christina K. Zigler, and Kathryn S. Torok. “Predictors of Longitudinal Quality of Life in Juvenile Localized Scleroderma.Arthritis Care Res (Hoboken) 69, no. 7 (July 2017): 1082–87. https://doi.org/10.1002/acr.23101.
Ardalan K, Zigler CK, Torok KS. Predictors of Longitudinal Quality of Life in Juvenile Localized Scleroderma. Arthritis Care Res (Hoboken). 2017 Jul;69(7):1082–7.
Ardalan, Kaveh, et al. “Predictors of Longitudinal Quality of Life in Juvenile Localized Scleroderma.Arthritis Care Res (Hoboken), vol. 69, no. 7, July 2017, pp. 1082–87. Pubmed, doi:10.1002/acr.23101.
Ardalan K, Zigler CK, Torok KS. Predictors of Longitudinal Quality of Life in Juvenile Localized Scleroderma. Arthritis Care Res (Hoboken). 2017 Jul;69(7):1082–1087.
Journal cover image

Published In

Arthritis Care Res (Hoboken)

DOI

EISSN

2151-4658

Publication Date

July 2017

Volume

69

Issue

7

Start / End Page

1082 / 1087

Location

United States

Related Subject Headings

  • Scleroderma, Localized
  • Quality of Life
  • Predictive Value of Tests
  • Male
  • Longitudinal Studies
  • Humans
  • Female
  • Cohort Studies
  • Child
  • Adolescent