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Retrospective study of haemophagocytic syndrome hospitalisations in children in the USA.

Publication ,  Journal Article
Badheka, A; Bangalore Prakash, P; Allareddy, V; Allareddy, V
Published in: BMJ Paediatr Open
2018

INTRODUCTION: The haemophagocytic syndrome (HS) is a rare condition that presents with uncontrolled inflammation leading to multiorgan failure and is associated with significant morbidity and mortality. Current national estimates of children hospitalised due to HS are unknown. Characterising and understanding the burden of HS-related hospitalisations at a national level is the initial step in optimising the overall care. METHODS: We performed a retrospective analysis of the Nationwide Inpatient Sample (NIS) from 2012 to 2014. The NIS is the largest all-payer inpatient care dataset in the USA that contains more than seven million hospital stays and its large sample size is ideal for developing national estimates of rare conditions. All patients aged up to 18 years who were primarily hospitalised due to HS were selected for our study. Descriptive statistics were used. A multitude of patient-level and hospital-level variables were assessed. Outcome variables included overall in-hospital mortality, hospital charges and the length of stay. RESULTS: A total of 840 patients aged up to 18 years were hospitalised primarily due to HS in the USA. Mean age was 5.7 years. 57.4% were males. Whites comprised 45%. 6.5% died in hospital. A vast majority (78%) were admitted on an emergency/urgent basis. The most frequent payers included Medicaid (50%) and private insurance (36.9%). Almost 80% of children had at least one comorbid condition. 96.3% of patients were treated in urban teaching hospitals. Southern regions accounted for 42.6% of all hospitalisations. The median length of stay in hospital was 9.6 days and the median hospitalisation charge was US$100 426. CONCLUSION: Nearly 1 in 15 children who were hospitalised due to HS died. The resource utilisation associated with HS-related hospitalisations is considerable. The majority of hospitalised children with HS had comorbid conditions.

Duke Scholars

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Published In

BMJ Paediatr Open

DOI

EISSN

2399-9772

Publication Date

2018

Volume

2

Issue

1

Start / End Page

e000337

Location

England

Related Subject Headings

  • 3213 Paediatrics
 

Citation

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MLA
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Badheka, A., Bangalore Prakash, P., & Allareddy, V. (2018). Retrospective study of haemophagocytic syndrome hospitalisations in children in the USA. BMJ Paediatr Open, 2(1), e000337. https://doi.org/10.1136/bmjpo-2018-000337
Badheka, Aditya, Pradeep Bangalore Prakash, Veerasathpurush Allareddy, and Veerajalandhar Allareddy. “Retrospective study of haemophagocytic syndrome hospitalisations in children in the USA.BMJ Paediatr Open 2, no. 1 (2018): e000337. https://doi.org/10.1136/bmjpo-2018-000337.
Badheka A, Bangalore Prakash P, Allareddy V. Retrospective study of haemophagocytic syndrome hospitalisations in children in the USA. BMJ Paediatr Open. 2018;2(1):e000337.
Badheka, Aditya, et al. “Retrospective study of haemophagocytic syndrome hospitalisations in children in the USA.BMJ Paediatr Open, vol. 2, no. 1, 2018, p. e000337. Pubmed, doi:10.1136/bmjpo-2018-000337.
Badheka A, Bangalore Prakash P, Allareddy V. Retrospective study of haemophagocytic syndrome hospitalisations in children in the USA. BMJ Paediatr Open. 2018;2(1):e000337.

Published In

BMJ Paediatr Open

DOI

EISSN

2399-9772

Publication Date

2018

Volume

2

Issue

1

Start / End Page

e000337

Location

England

Related Subject Headings

  • 3213 Paediatrics