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Cholinergic suppression of visual responses in primate V1 is mediated by GABAergic inhibition

Publication ,  Journal Article
Disney, AA; Aoki, C; Hawken, MJ
Published in: Journal of Neurophysiology
October 1, 2012

Acetylcholine (ACh) has been implicated in selective attention. To understand the local circuit action of ACh, we iontophoresed cholinergic agonists into the primate primary visual cortex (V1) while presenting optimal visual stimuli. Consistent with our previous anatomical studies showing that GABAergic neurons in V1 express ACh receptors to a greater extent than do excitatory neurons, we observed suppressed visual responses in 36% of recorded neurons outside V1's primary thalamorecipient layer (4c). This suppression is blocked by the GABA receptor antagonist gabazine. Within layer 4c, ACh release produces a response gain enhancement (Disney AA, Aoki C, Hawken MJ. Neuron 56: 701–713, 2007); elsewhere, ACh suppresses response gain by strengthening inhibition. Our finding contrasts with the observation that the dominant mechanism of suppression in the neocortex of rats is reduced glutamate release. We propose that in primates, distinct cholinergic receptor subtypes are recruited on specific cell types and in specific lamina to yield opposing modulatory effects that together increase neurons' responsiveness to optimal stimuli without changing tuning width.

Duke Scholars

Published In

Journal of Neurophysiology

DOI

EISSN

1522-1598

ISSN

0022-3077

Publication Date

October 1, 2012

Volume

108

Issue

7

Start / End Page

1907 / 1923

Publisher

American Physiological Society

Related Subject Headings

  • Neurology & Neurosurgery
  • 17 Psychology and Cognitive Sciences
  • 11 Medical and Health Sciences
 

Citation

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Disney, A. A., Aoki, C., & Hawken, M. J. (2012). Cholinergic suppression of visual responses in primate V1 is mediated by GABAergic inhibition. Journal of Neurophysiology, 108(7), 1907–1923. https://doi.org/10.1152/jn.00188.2012
Disney, Anita A., Chiye Aoki, and Michael J. Hawken. “Cholinergic suppression of visual responses in primate V1 is mediated by GABAergic inhibition.” Journal of Neurophysiology 108, no. 7 (October 1, 2012): 1907–23. https://doi.org/10.1152/jn.00188.2012.
Disney AA, Aoki C, Hawken MJ. Cholinergic suppression of visual responses in primate V1 is mediated by GABAergic inhibition. Journal of Neurophysiology. 2012 Oct 1;108(7):1907–23.
Disney, Anita A., et al. “Cholinergic suppression of visual responses in primate V1 is mediated by GABAergic inhibition.” Journal of Neurophysiology, vol. 108, no. 7, American Physiological Society, Oct. 2012, pp. 1907–23. Crossref, doi:10.1152/jn.00188.2012.
Disney AA, Aoki C, Hawken MJ. Cholinergic suppression of visual responses in primate V1 is mediated by GABAergic inhibition. Journal of Neurophysiology. American Physiological Society; 2012 Oct 1;108(7):1907–1923.

Published In

Journal of Neurophysiology

DOI

EISSN

1522-1598

ISSN

0022-3077

Publication Date

October 1, 2012

Volume

108

Issue

7

Start / End Page

1907 / 1923

Publisher

American Physiological Society

Related Subject Headings

  • Neurology & Neurosurgery
  • 17 Psychology and Cognitive Sciences
  • 11 Medical and Health Sciences