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Microbiota of Inflammatory Bowel Disease Models.

Publication ,  Conference
Gao, Z; Chen, K-Y; Mueller, O; Zhang, H; Rakhilin, N; Chen, J; Shen, X
Published in: Annu Int Conf IEEE Eng Med Biol Soc
July 2018

Gut microbiome plays an important role in inflammatory bowel disease (IBD), a group of intestinal chronic inflammation conditions that affect a large population. The animal models of IBD have long been established on basis of pathological features, but their ability to recapitulate patient gut microbiota is unknown. We investigated and compared the composition and biodiversity of bacterial population in the fecal samples from rat models of the two IBD subtypes, and compared them with patient samples. Our analyses revealed that inflammation reduces overall microbiome diversity and increased variation between individuals. We identified specific microbial signatures associated with the two IBD subtypes that were consistent between the animal models and human IBD patients, suggesting that the animal models can partially recapitulate the microbiota in human diseases. Furthermore, metagenome prediction analysis suggested microbial functions that were likely altered by host-microbiota interactions in IBD models.

Duke Scholars

Published In

Annu Int Conf IEEE Eng Med Biol Soc

DOI

EISSN

2694-0604

Publication Date

July 2018

Volume

2018

Start / End Page

2374 / 2377

Location

United States

Related Subject Headings

  • Rats
  • Male
  • Intestines
  • Inflammatory Bowel Diseases
  • Humans
  • Gastrointestinal Microbiome
  • Feces
  • Disease Models, Animal
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Gao, Z., Chen, K.-Y., Mueller, O., Zhang, H., Rakhilin, N., Chen, J., & Shen, X. (2018). Microbiota of Inflammatory Bowel Disease Models. In Annu Int Conf IEEE Eng Med Biol Soc (Vol. 2018, pp. 2374–2377). United States. https://doi.org/10.1109/EMBC.2018.8512848
Gao, Ziyang, Kai-Yuan Chen, Olaf Mueller, Han Zhang, Nikolai Rakhilin, Jiande Chen, and Xiling Shen. “Microbiota of Inflammatory Bowel Disease Models.” In Annu Int Conf IEEE Eng Med Biol Soc, 2018:2374–77, 2018. https://doi.org/10.1109/EMBC.2018.8512848.
Gao Z, Chen K-Y, Mueller O, Zhang H, Rakhilin N, Chen J, et al. Microbiota of Inflammatory Bowel Disease Models. In: Annu Int Conf IEEE Eng Med Biol Soc. 2018. p. 2374–7.
Gao, Ziyang, et al. “Microbiota of Inflammatory Bowel Disease Models.Annu Int Conf IEEE Eng Med Biol Soc, vol. 2018, 2018, pp. 2374–77. Pubmed, doi:10.1109/EMBC.2018.8512848.
Gao Z, Chen K-Y, Mueller O, Zhang H, Rakhilin N, Chen J, Shen X. Microbiota of Inflammatory Bowel Disease Models. Annu Int Conf IEEE Eng Med Biol Soc. 2018. p. 2374–2377.

Published In

Annu Int Conf IEEE Eng Med Biol Soc

DOI

EISSN

2694-0604

Publication Date

July 2018

Volume

2018

Start / End Page

2374 / 2377

Location

United States

Related Subject Headings

  • Rats
  • Male
  • Intestines
  • Inflammatory Bowel Diseases
  • Humans
  • Gastrointestinal Microbiome
  • Feces
  • Disease Models, Animal
  • Animals