Skip to main content
Journal cover image

Structure and function of dual-source cholinergic modulation in early vision.

Publication ,  Journal Article
Krueger, J; Disney, AA
Published in: J Comp Neurol
February 15, 2019

Behavioral states such as arousal and attention have profound effects on sensory processing, determining how-even whether-a stimulus is perceived. This state-dependence is believed to arise, at least in part, in response to inputs from subcortical structures that release neuromodulators such as acetylcholine, often nonsynaptically. The mechanisms that underlie the interaction between these nonsynaptic signals and the more point-to-point synaptic cortical circuitry are not well understood. This review highlights the state of the field, with a focus on cholinergic action in early visual processing. Key anatomical and physiological features of both the cholinergic and the visual systems are discussed. Furthermore, presenting evidence of cholinergic modulation in visual thalamus and primary visual cortex, we explore potential functional roles of acetylcholine and its effects on the processing of visual input over the sleep-wake cycle, sensory gain control during wakefulness, and consider evidence for cholinergic support of visual attention.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Comp Neurol

DOI

EISSN

1096-9861

Publication Date

February 15, 2019

Volume

527

Issue

3

Start / End Page

738 / 750

Location

United States

Related Subject Headings

  • Visual Pathways
  • Visual Cortex
  • Neurology & Neurosurgery
  • Humans
  • Cholinergic Neurons
  • Attention
  • Animals
  • Acetylcholine
  • 3209 Neurosciences
  • 3109 Zoology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Krueger, J., & Disney, A. A. (2019). Structure and function of dual-source cholinergic modulation in early vision. J Comp Neurol, 527(3), 738–750. https://doi.org/10.1002/cne.24590
Krueger, Juliane, and Anita A. Disney. “Structure and function of dual-source cholinergic modulation in early vision.J Comp Neurol 527, no. 3 (February 15, 2019): 738–50. https://doi.org/10.1002/cne.24590.
Krueger J, Disney AA. Structure and function of dual-source cholinergic modulation in early vision. J Comp Neurol. 2019 Feb 15;527(3):738–50.
Krueger, Juliane, and Anita A. Disney. “Structure and function of dual-source cholinergic modulation in early vision.J Comp Neurol, vol. 527, no. 3, Feb. 2019, pp. 738–50. Pubmed, doi:10.1002/cne.24590.
Krueger J, Disney AA. Structure and function of dual-source cholinergic modulation in early vision. J Comp Neurol. 2019 Feb 15;527(3):738–750.
Journal cover image

Published In

J Comp Neurol

DOI

EISSN

1096-9861

Publication Date

February 15, 2019

Volume

527

Issue

3

Start / End Page

738 / 750

Location

United States

Related Subject Headings

  • Visual Pathways
  • Visual Cortex
  • Neurology & Neurosurgery
  • Humans
  • Cholinergic Neurons
  • Attention
  • Animals
  • Acetylcholine
  • 3209 Neurosciences
  • 3109 Zoology