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Engineering Controlled Peritumoral Inflammation to Constrain Brain Tumor Growth.

Publication ,  Journal Article
Saxena, T; Lyon, JG; Pai, SB; Pare, D; Amero, J; Karumbaiah, L; Carroll, SL; Gaupp, E; Bellamkonda, RV
Published in: Advanced healthcare materials
February 2019

Brain tumors remain a great clinical challenge, in part due to their capacity to invade into eloquent, inoperable regions of the brain. In contrast, inflammation in the central nervous system (CNS) due to injuries activates microglia and astrocytes culminating in an astroglial scar that typically "walls-off" the injury site. Here, the hypothesis is tested that targeting peritumoral cells surrounding tumors to activate them via an inflammatory stimulus that recapitulates the sequelae of a traumatic CNS injury, could generate an environment that would wall-off and contain invasive tumors in the brain. Gold nanoparticles coated with inflammatory polypeptides to target stromal cells in close vicinity to glioblastoma (GBM) tumors, in order to activate these cells and stimulate stromal CNS inflammation, are engineered. It is reported that this approach significantly contains tumors in rodent models of GBM relative to control treatments (reduction in tumor volume by over 300% in comparison to controls), by the activation of the innate and adaptive immune response, and by triggering pathways related to cell clustering. Overall, this report outlines an approach to contain invasive tumors that can complement adjuvant interventions for invasive GBM such as radiation and chemotherapy.

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Published In

Advanced healthcare materials

DOI

EISSN

2192-2659

ISSN

2192-2640

Publication Date

February 2019

Volume

8

Issue

4

Start / End Page

e1801076

Related Subject Headings

  • Rats, Nude
  • Rats
  • Microglia
  • Mice
  • Inflammation
  • Immunity, Innate
  • Humans
  • Glioblastoma
  • Cell Line, Tumor
  • Brain Neoplasms
 

Citation

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Saxena, T., Lyon, J. G., Pai, S. B., Pare, D., Amero, J., Karumbaiah, L., … Bellamkonda, R. V. (2019). Engineering Controlled Peritumoral Inflammation to Constrain Brain Tumor Growth. Advanced Healthcare Materials, 8(4), e1801076. https://doi.org/10.1002/adhm.201801076
Saxena, Tarun, Johnathan G. Lyon, S Balakrishna Pai, Daniel Pare, Jessica Amero, Lohitash Karumbaiah, Sheridan L. Carroll, Eric Gaupp, and Ravi V. Bellamkonda. “Engineering Controlled Peritumoral Inflammation to Constrain Brain Tumor Growth.Advanced Healthcare Materials 8, no. 4 (February 2019): e1801076. https://doi.org/10.1002/adhm.201801076.
Saxena T, Lyon JG, Pai SB, Pare D, Amero J, Karumbaiah L, et al. Engineering Controlled Peritumoral Inflammation to Constrain Brain Tumor Growth. Advanced healthcare materials. 2019 Feb;8(4):e1801076.
Saxena, Tarun, et al. “Engineering Controlled Peritumoral Inflammation to Constrain Brain Tumor Growth.Advanced Healthcare Materials, vol. 8, no. 4, Feb. 2019, p. e1801076. Epmc, doi:10.1002/adhm.201801076.
Saxena T, Lyon JG, Pai SB, Pare D, Amero J, Karumbaiah L, Carroll SL, Gaupp E, Bellamkonda RV. Engineering Controlled Peritumoral Inflammation to Constrain Brain Tumor Growth. Advanced healthcare materials. 2019 Feb;8(4):e1801076.
Journal cover image

Published In

Advanced healthcare materials

DOI

EISSN

2192-2659

ISSN

2192-2640

Publication Date

February 2019

Volume

8

Issue

4

Start / End Page

e1801076

Related Subject Headings

  • Rats, Nude
  • Rats
  • Microglia
  • Mice
  • Inflammation
  • Immunity, Innate
  • Humans
  • Glioblastoma
  • Cell Line, Tumor
  • Brain Neoplasms