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The Impact of Location of Progressive Visual Field Loss on Longitudinal Changes in Quality of Life of Patients with Glaucoma.

Publication ,  Journal Article
Abe, RY; Diniz-Filho, A; Costa, VP; Gracitelli, CPB; Baig, S; Medeiros, FA
Published in: Ophthalmology
March 2016

PURPOSE: To evaluate the association between rates of progressive loss in different regions of the visual field and longitudinal changes in quality of life (QoL). DESIGN: Prospective, observational cohort study. PARTICIPANTS: The study included 236 patients with glaucomatous visual field loss followed for an average of 4.3±1.5 years. METHODS: All subjects had the 25-item National Eye Institute Visual Functioning Questionnaire (NEI VFQ-25) performed annually and standard automated perimetry (SAP) at 6-month intervals. Subjects were included if they had a minimum of 2 NEI VFQ-25 and 5 SAP tests during follow-up. Evaluation of rates of visual field change was performed using 4 different regions (central inferior, central superior, peripheral inferior, and peripheral superior) of the integrated binocular visual field. The association between change in NEI VFQ-25 Rasch-calibrated scores and change in different regions of the visual field was investigated with a joint multivariable longitudinal linear mixed model. MAIN OUTCOME MEASURES: The relationship between change in QoL scores and change of mean sensitivity in different regions of the visual field. RESULTS: There was a significant correlation between change in the NEI VFQ-25 Rasch scores during follow-up and change in different regions of the visual field. Each 1 decibel (dB)/year change in binocular mean sensitivity of the central inferior area was associated with a decline of 2.6 units/year in the NEI VFQ-25 scores (R(2) = 35%; P < 0.001). Corresponding associations with change in QoL scores for the peripheral inferior, central superior, and peripheral superior areas of the visual field had R(2) values of 30%, 24%, and 19%, respectively. The association for the central inferior visual field area was statistically significantly stronger than those of the central superior area (P = 0.011) and peripheral superior area (P = 0.001), but not the peripheral inferior area (P = 0.171). Greater declines in NEI VFQ-25 scores were also seen in patients who had worse visual field sensitivity at baseline. CONCLUSIONS: Progressive decline in sensitivity in the central inferior area of the visual field had the strongest association with longitudinal decline in QoL of patients with glaucoma.

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Published In

Ophthalmology

DOI

EISSN

1549-4713

Publication Date

March 2016

Volume

123

Issue

3

Start / End Page

552 / 557

Location

United States

Related Subject Headings

  • Visual Fields
  • Visual Field Tests
  • Vision Disorders
  • Surveys and Questionnaires
  • Sickness Impact Profile
  • Sensitivity and Specificity
  • Quality of Life
  • Prospective Studies
  • Ophthalmology & Optometry
  • Middle Aged
 

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Abe, R. Y., Diniz-Filho, A., Costa, V. P., Gracitelli, C. P. B., Baig, S., & Medeiros, F. A. (2016). The Impact of Location of Progressive Visual Field Loss on Longitudinal Changes in Quality of Life of Patients with Glaucoma. Ophthalmology, 123(3), 552–557. https://doi.org/10.1016/j.ophtha.2015.10.046
Abe, Ricardo Y., Alberto Diniz-Filho, Vital P. Costa, Carolina P. B. Gracitelli, Saif Baig, and Felipe A. Medeiros. “The Impact of Location of Progressive Visual Field Loss on Longitudinal Changes in Quality of Life of Patients with Glaucoma.Ophthalmology 123, no. 3 (March 2016): 552–57. https://doi.org/10.1016/j.ophtha.2015.10.046.
Abe RY, Diniz-Filho A, Costa VP, Gracitelli CPB, Baig S, Medeiros FA. The Impact of Location of Progressive Visual Field Loss on Longitudinal Changes in Quality of Life of Patients with Glaucoma. Ophthalmology. 2016 Mar;123(3):552–7.
Abe, Ricardo Y., et al. “The Impact of Location of Progressive Visual Field Loss on Longitudinal Changes in Quality of Life of Patients with Glaucoma.Ophthalmology, vol. 123, no. 3, Mar. 2016, pp. 552–57. Pubmed, doi:10.1016/j.ophtha.2015.10.046.
Abe RY, Diniz-Filho A, Costa VP, Gracitelli CPB, Baig S, Medeiros FA. The Impact of Location of Progressive Visual Field Loss on Longitudinal Changes in Quality of Life of Patients with Glaucoma. Ophthalmology. 2016 Mar;123(3):552–557.
Journal cover image

Published In

Ophthalmology

DOI

EISSN

1549-4713

Publication Date

March 2016

Volume

123

Issue

3

Start / End Page

552 / 557

Location

United States

Related Subject Headings

  • Visual Fields
  • Visual Field Tests
  • Vision Disorders
  • Surveys and Questionnaires
  • Sickness Impact Profile
  • Sensitivity and Specificity
  • Quality of Life
  • Prospective Studies
  • Ophthalmology & Optometry
  • Middle Aged