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Semiautomated quantification of β-zone parapapillary atrophy using blue light fundus autofluorescence.

Publication ,  Journal Article
Mansouri, K; Tung, JD; Medeiros, FA; Tafreshi, A; Dorairaj, S; Zangwill, L; He, F; Jain, S; Weinreb, RN
Published in: Acta Ophthalmol
August 2013

PURPOSE: To evaluate the reproducibility of measurements of area of β-zone parapapillary atrophy (β-PPA) using blue laser fundus autofluorescence (FAF) and confocal scanning laser ophthalmoscopy reflectance (CSLO) measurements and to assess agreement between the two imaging modalities. METHODS: Sixty-five eyes of 45 patients (mean age, 68.2 ± 11.3 years) with established or suspected glaucoma from the Diagnostic Innovations in Glaucoma Study (DIGS) were prospectively included. FAF scans were obtained with the Spectralis HRA+OCT and CSLO reflectance images with the HRTII (both from Heidelberg Engineering, Heidelberg, Germany). Two masked graders independently measured β-PPA area on 3 consecutive scans using the semi-automated BluePeak RegionFinder software (BPRF) and on CSLO reflectance images using the optic disc contour line. Reproducibility of β-PPA area measurements was assessed using intraclass correlation coefficients (ICC). RESULTS: Intragrader reproducibility was 0.997 (95% CI, 0.996-0.998) and 0.995 (95% CI, 0.992-0.996) for grader 1 and 2, respectively, using FAF-BPRF, and by CSLO, it was 0.991 (95% CI, 0.986-0.994) and 0.988 (95% CI, 0.982-0.992). Intergrader agreement (ICC) was 0.53 (95% CI, 0.331-0.685) for FAF-BPRF and 0.404 (95% CI, 0.149-0.601) for CSLO (comparison between ICC, p = 0.368). Agreement (ICC) between the two devices was worse for grader 1 (0.356; 95% CI, 0.129-0.549) than grader 2 (0.856; 95% CI, 0.774-0.910) (p < 0.001). CONCLUSIONS: Despite excellent intragrader reproducibility for β-PPA measurements with FAF-BPRF and CSLO, intergrader reproducibility is low to moderate. Measurements of β-PPA area obtained with the two instruments are of moderate agreement and, therefore, are not interchangeable.

Duke Scholars

Published In

Acta Ophthalmol

DOI

EISSN

1755-3768

Publication Date

August 2013

Volume

91

Issue

5

Start / End Page

e379 / e385

Location

England

Related Subject Headings

  • Tomography, Optical Coherence
  • Reproducibility of Results
  • Prospective Studies
  • Optic Disk
  • Optic Atrophy
  • Ophthalmoscopy
  • Ophthalmology & Optometry
  • Ocular Hypertension
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
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Mansouri, K., Tung, J. D., Medeiros, F. A., Tafreshi, A., Dorairaj, S., Zangwill, L., … Weinreb, R. N. (2013). Semiautomated quantification of β-zone parapapillary atrophy using blue light fundus autofluorescence. Acta Ophthalmol, 91(5), e379–e385. https://doi.org/10.1111/aos.12057
Mansouri, Kaweh, Jonathan D. Tung, Felipe A. Medeiros, Ali Tafreshi, Syril Dorairaj, Linda Zangwill, Feng He, Sonia Jain, and Robert N. Weinreb. “Semiautomated quantification of β-zone parapapillary atrophy using blue light fundus autofluorescence.Acta Ophthalmol 91, no. 5 (August 2013): e379–85. https://doi.org/10.1111/aos.12057.
Mansouri K, Tung JD, Medeiros FA, Tafreshi A, Dorairaj S, Zangwill L, et al. Semiautomated quantification of β-zone parapapillary atrophy using blue light fundus autofluorescence. Acta Ophthalmol. 2013 Aug;91(5):e379–85.
Mansouri, Kaweh, et al. “Semiautomated quantification of β-zone parapapillary atrophy using blue light fundus autofluorescence.Acta Ophthalmol, vol. 91, no. 5, Aug. 2013, pp. e379–85. Pubmed, doi:10.1111/aos.12057.
Mansouri K, Tung JD, Medeiros FA, Tafreshi A, Dorairaj S, Zangwill L, He F, Jain S, Weinreb RN. Semiautomated quantification of β-zone parapapillary atrophy using blue light fundus autofluorescence. Acta Ophthalmol. 2013 Aug;91(5):e379–e385.
Journal cover image

Published In

Acta Ophthalmol

DOI

EISSN

1755-3768

Publication Date

August 2013

Volume

91

Issue

5

Start / End Page

e379 / e385

Location

England

Related Subject Headings

  • Tomography, Optical Coherence
  • Reproducibility of Results
  • Prospective Studies
  • Optic Disk
  • Optic Atrophy
  • Ophthalmoscopy
  • Ophthalmology & Optometry
  • Ocular Hypertension
  • Middle Aged
  • Male