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Analysis of continuous 24-hour intraocular pressure patterns in glaucoma.

Publication ,  Journal Article
Mansouri, K; Liu, JHK; Weinreb, RN; Tafreshi, A; Medeiros, FA
Published in: Invest Ophthalmol Vis Sci
December 13, 2012

PURPOSE: To present a method to analyze circadian intraocular pressure (IOP) patterns in glaucoma patients and suspects undergoing repeated continuous 24-hour IOP monitoring. METHODS: Forty patients with established (n = 19) or suspected glaucoma (n = 21) underwent ambulatory 24-hour IOP monitoring on two sessions 1 week apart using a contact lens sensor (CLS). The CLS provides its output in arbitrary units (a.u.). A modified cosinor rhythmometry method was adapted to the CLS output to analyze 24-hour IOP patterns and their reproducibility. Nonparametric tests were used to study differences between sessions 1 and 2 (S1 and S2). Patients pursued their routine daily activities and their sleep was uncontrolled. CLS data were used to assess sleep times. RESULTS: Complete 24-hour data from both sessions were available for 35 patients. Mean (SD) age of the patients was 55.8 ± 15.5 years. The correlation of the cosinor fitting and measured CLS values was r = 0.38 (Spearman r; P < 0.001) for S1, r = 0.50 (P < 0.001) for S2, whereas the correlation between S1 and S2 cosinor fittings was r = 0.76 (P < 0.001). Repeated nocturnal acrophase was seen in 62.9% of patients; 17.1% of patients had no repeatable acrophase. The average amplitude of the 24-hour curve was 143.6 ± 108.1 a.u. (S1) and 130.8 ± 68.2 a.u. (S2) (P = 0.936). CONCLUSIONS: Adapting the cosinor method to CLS data is a useful way for modeling the rhythmic nature of 24-hour IOP patterns and evaluating their reproducibility. Repeatable nocturnal acrophase was seen in 62.9% of patients. (ClinicalTrials.gov number, NCT01319617.).

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Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

December 13, 2012

Volume

53

Issue

13

Start / End Page

8050 / 8056

Location

United States

Related Subject Headings

  • Tonometry, Ocular
  • Ophthalmology & Optometry
  • Ocular Hypertension
  • Monitoring, Physiologic
  • Middle Aged
  • Male
  • Intraocular Pressure
  • Humans
  • Gonioscopy
  • Glaucoma, Open-Angle
 

Citation

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ICMJE
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Mansouri, K., Liu, J. H. K., Weinreb, R. N., Tafreshi, A., & Medeiros, F. A. (2012). Analysis of continuous 24-hour intraocular pressure patterns in glaucoma. Invest Ophthalmol Vis Sci, 53(13), 8050–8056. https://doi.org/10.1167/iovs.12-10569
Mansouri, Kaweh, John H. K. Liu, Robert N. Weinreb, Ali Tafreshi, and Felipe A. Medeiros. “Analysis of continuous 24-hour intraocular pressure patterns in glaucoma.Invest Ophthalmol Vis Sci 53, no. 13 (December 13, 2012): 8050–56. https://doi.org/10.1167/iovs.12-10569.
Mansouri K, Liu JHK, Weinreb RN, Tafreshi A, Medeiros FA. Analysis of continuous 24-hour intraocular pressure patterns in glaucoma. Invest Ophthalmol Vis Sci. 2012 Dec 13;53(13):8050–6.
Mansouri, Kaweh, et al. “Analysis of continuous 24-hour intraocular pressure patterns in glaucoma.Invest Ophthalmol Vis Sci, vol. 53, no. 13, Dec. 2012, pp. 8050–56. Pubmed, doi:10.1167/iovs.12-10569.
Mansouri K, Liu JHK, Weinreb RN, Tafreshi A, Medeiros FA. Analysis of continuous 24-hour intraocular pressure patterns in glaucoma. Invest Ophthalmol Vis Sci. 2012 Dec 13;53(13):8050–8056.

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

December 13, 2012

Volume

53

Issue

13

Start / End Page

8050 / 8056

Location

United States

Related Subject Headings

  • Tonometry, Ocular
  • Ophthalmology & Optometry
  • Ocular Hypertension
  • Monitoring, Physiologic
  • Middle Aged
  • Male
  • Intraocular Pressure
  • Humans
  • Gonioscopy
  • Glaucoma, Open-Angle