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A comparison of rates of change in neuroretinal rim area and retinal nerve fiber layer thickness in progressive glaucoma.

Publication ,  Journal Article
Alencar, LM; Zangwill, LM; Weinreb, RN; Bowd, C; Sample, PA; Girkin, CA; Liebmann, JM; Medeiros, FA
Published in: Invest Ophthalmol Vis Sci
July 2010

PURPOSE. To evaluate and compare rates of change in neuroretinal rim area (RA) and retinal nerve fiber layer thickness (RNFLT) measurements in glaucoma patients, those with suspected glaucoma, and normal subjects observed over time. METHODS. In this observational cohort study, patients recruited from two longitudinal studies (Diagnostic Innovations in Glaucoma Study-DIGS and African Descent and Evaluation Study-ADAGES) were observed with standard achromatic perimetry (SAP), optic disc stereophotographs, confocal scanning laser ophthalmoscopy (HRT-3; Heidelberg Engineering, Heidelberg, Germany), and scanning laser polarimetry (GDx-VCC; Carl Zeiss Meditec, Inc., Dublin, CA). Glaucoma progression was determined by the Guided Progression Analysis software for standard automated perimetry [SAP] and by masked assessment of serial optic disc stereophotographs by expert graders. Random-coefficients models were used to evaluate rates of change in average RNFLT and global RA measurements and their relationship with glaucoma progression. RESULTS. At baseline, 194 (31%) eyes were glaucomatous, 347 (55%) had suspected glaucoma, and 88 (14%) were normal. Forty-six (9%) eyes showed progression by SAP and/or stereophotographs, during an average follow-up of 3.3 (+/-0.7) years. The average rate of decline for RNFLT measurements was significantly higher in the progressing group than in the nonprogressing group (-0.65 vs. -0.11 microm/y, respectively; P < 0.001), whereas RA decline was not significantly different between these groups (-0.0058 vs. -0.0073 mm(2)/y, respectively; P = 0.727). The areas under the receiver operating characteristic (ROC) curves used to discriminate progressing versus nonprogressing eyes were 0.811 and 0.507 for the rates of change in the RNFLT and RA, respectively (P < 0.001). CONCLUSIONS. The ability to discriminate eyes with progressing glaucoma by SAP and/or stereophotographs from stable eyes was significantly greater for RNFLT than for RA measurements.

Duke Scholars

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

July 2010

Volume

51

Issue

7

Start / End Page

3531 / 3539

Location

United States

Related Subject Headings

  • Visual Fields
  • Visual Field Tests
  • Tomography, Optical Coherence
  • Scanning Laser Polarimetry
  • Retinal Ganglion Cells
  • Optic Disk
  • Ophthalmoscopy
  • Ophthalmology & Optometry
  • Ocular Hypertension
  • Nerve Fibers
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Alencar, L. M., Zangwill, L. M., Weinreb, R. N., Bowd, C., Sample, P. A., Girkin, C. A., … Medeiros, F. A. (2010). A comparison of rates of change in neuroretinal rim area and retinal nerve fiber layer thickness in progressive glaucoma. Invest Ophthalmol Vis Sci, 51(7), 3531–3539. https://doi.org/10.1167/iovs.09-4350
Alencar, Luciana M., Linda M. Zangwill, Robert N. Weinreb, Christopher Bowd, Pamela A. Sample, Christopher A. Girkin, Jeffrey M. Liebmann, and Felipe A. Medeiros. “A comparison of rates of change in neuroretinal rim area and retinal nerve fiber layer thickness in progressive glaucoma.Invest Ophthalmol Vis Sci 51, no. 7 (July 2010): 3531–39. https://doi.org/10.1167/iovs.09-4350.
Alencar LM, Zangwill LM, Weinreb RN, Bowd C, Sample PA, Girkin CA, et al. A comparison of rates of change in neuroretinal rim area and retinal nerve fiber layer thickness in progressive glaucoma. Invest Ophthalmol Vis Sci. 2010 Jul;51(7):3531–9.
Alencar, Luciana M., et al. “A comparison of rates of change in neuroretinal rim area and retinal nerve fiber layer thickness in progressive glaucoma.Invest Ophthalmol Vis Sci, vol. 51, no. 7, July 2010, pp. 3531–39. Pubmed, doi:10.1167/iovs.09-4350.
Alencar LM, Zangwill LM, Weinreb RN, Bowd C, Sample PA, Girkin CA, Liebmann JM, Medeiros FA. A comparison of rates of change in neuroretinal rim area and retinal nerve fiber layer thickness in progressive glaucoma. Invest Ophthalmol Vis Sci. 2010 Jul;51(7):3531–3539.

Published In

Invest Ophthalmol Vis Sci

DOI

EISSN

1552-5783

Publication Date

July 2010

Volume

51

Issue

7

Start / End Page

3531 / 3539

Location

United States

Related Subject Headings

  • Visual Fields
  • Visual Field Tests
  • Tomography, Optical Coherence
  • Scanning Laser Polarimetry
  • Retinal Ganglion Cells
  • Optic Disk
  • Ophthalmoscopy
  • Ophthalmology & Optometry
  • Ocular Hypertension
  • Nerve Fibers