Treatment of xerophthalmia with retinol, tretinoin, and etretinate.
Publication
, Journal Article
Hatchell, DL; Faculjak, M; Kubicek, D
Published in: Arch Ophthalmol
June 1984
Topical retinol, tretinoin (all-trans-retinoic acid) and etretinate (a synthetic retinoid) were used in rabbits to treat experimental xerophthalmia due to vitamin A deficiency. Both 0.2% retinol and 0.1% and 0.2% tretinoin effectively reversed abnormal corneal epithelial keratinization within one to two days and restored corneal clarity within two to four days following topical application three times per day. Etretinate was ineffective in the concentration used (0.2%). In addition, application of tretinoin to one eye effectively reversed xerophthalmic changes in the other eye. Retinol did not have an effect on the other eye.
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Published In
Arch Ophthalmol
DOI
ISSN
0003-9950
Publication Date
June 1984
Volume
102
Issue
6
Start / End Page
926 / 927
Location
United States
Related Subject Headings
- Xerophthalmia
- Vitamin A
- Tretinoin
- Retinoids
- Rabbits
- Ophthalmology & Optometry
- Etretinate
- Drug Evaluation, Preclinical
- Animals
- Administration, Topical
Citation
APA
Chicago
ICMJE
MLA
NLM
Hatchell, D. L., Faculjak, M., & Kubicek, D. (1984). Treatment of xerophthalmia with retinol, tretinoin, and etretinate. Arch Ophthalmol, 102(6), 926–927. https://doi.org/10.1001/archopht.1984.01040030746036
Hatchell, D. L., M. Faculjak, and D. Kubicek. “Treatment of xerophthalmia with retinol, tretinoin, and etretinate.” Arch Ophthalmol 102, no. 6 (June 1984): 926–27. https://doi.org/10.1001/archopht.1984.01040030746036.
Hatchell DL, Faculjak M, Kubicek D. Treatment of xerophthalmia with retinol, tretinoin, and etretinate. Arch Ophthalmol. 1984 Jun;102(6):926–7.
Hatchell, D. L., et al. “Treatment of xerophthalmia with retinol, tretinoin, and etretinate.” Arch Ophthalmol, vol. 102, no. 6, June 1984, pp. 926–27. Pubmed, doi:10.1001/archopht.1984.01040030746036.
Hatchell DL, Faculjak M, Kubicek D. Treatment of xerophthalmia with retinol, tretinoin, and etretinate. Arch Ophthalmol. 1984 Jun;102(6):926–927.
Published In
Arch Ophthalmol
DOI
ISSN
0003-9950
Publication Date
June 1984
Volume
102
Issue
6
Start / End Page
926 / 927
Location
United States
Related Subject Headings
- Xerophthalmia
- Vitamin A
- Tretinoin
- Retinoids
- Rabbits
- Ophthalmology & Optometry
- Etretinate
- Drug Evaluation, Preclinical
- Animals
- Administration, Topical