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Chlamydia Persistence: A Survival Strategy to Evade Antimicrobial Effects in-vitro and in-vivo.

Publication ,  Journal Article
Panzetta, ME; Valdivia, RH; Saka, HA
Published in: Front Microbiol
2018

The Chlamydiaceae comprise a group of highly adapted bacterial pathogens sharing a unique intracellular lifestyle. Three Chlamydia species are pathogenic to humans: Chlamydia trachomatis, Chlamydia pneumoniae, and Chlamydia psittaci. C. trachomatis is the leading bacterial cause of sexually-transmitted infections and infectious blindness worldwide. Chlamydia pneumoniae is a major cause of community-acquired atypical pneumonia. C. psittaci primarily affects psittacine birds and can be transmitted to humans causing psittacosis, a potentially fatal form of pneumonia. As opposed to other bacterial pathogens, the spread of clinically relevant antimicrobial resistance genes does not seem to be a major problem for the treatment of Chlamydia infections. However, when exposed to stressing conditions, like those arising from exposure to antimicrobial stimuli, these bacteria undergo a temporary interruption in their replication cycle and enter a viable but non-cultivable state known as persistence. When the stressing conditions are removed, Chlamydia resumes replication and generation of infectious particles. This review gives an overview of the different survival strategies used by Chlamydia to evade the deleterious effects of penicillin and IFNγ, with a focus on the different models used to study Chlamydia persistence, their contribution to elucidating the molecular basis of this complex phenomenon and their potential implications for studies in animal models of infection.

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Published In

Front Microbiol

DOI

ISSN

1664-302X

Publication Date

2018

Volume

9

Start / End Page

3101

Location

Switzerland

Related Subject Headings

  • 3207 Medical microbiology
  • 3107 Microbiology
  • 0605 Microbiology
  • 0503 Soil Sciences
  • 0502 Environmental Science and Management
 

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Panzetta, M. E., Valdivia, R. H., & Saka, H. A. (2018). Chlamydia Persistence: A Survival Strategy to Evade Antimicrobial Effects in-vitro and in-vivo. Front Microbiol, 9, 3101. https://doi.org/10.3389/fmicb.2018.03101
Panzetta, Maria Emilia, Raphael H. Valdivia, and Hector Alex Saka. “Chlamydia Persistence: A Survival Strategy to Evade Antimicrobial Effects in-vitro and in-vivo.Front Microbiol 9 (2018): 3101. https://doi.org/10.3389/fmicb.2018.03101.
Panzetta ME, Valdivia RH, Saka HA. Chlamydia Persistence: A Survival Strategy to Evade Antimicrobial Effects in-vitro and in-vivo. Front Microbiol. 2018;9:3101.
Panzetta, Maria Emilia, et al. “Chlamydia Persistence: A Survival Strategy to Evade Antimicrobial Effects in-vitro and in-vivo.Front Microbiol, vol. 9, 2018, p. 3101. Pubmed, doi:10.3389/fmicb.2018.03101.
Panzetta ME, Valdivia RH, Saka HA. Chlamydia Persistence: A Survival Strategy to Evade Antimicrobial Effects in-vitro and in-vivo. Front Microbiol. 2018;9:3101.

Published In

Front Microbiol

DOI

ISSN

1664-302X

Publication Date

2018

Volume

9

Start / End Page

3101

Location

Switzerland

Related Subject Headings

  • 3207 Medical microbiology
  • 3107 Microbiology
  • 0605 Microbiology
  • 0503 Soil Sciences
  • 0502 Environmental Science and Management