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Pulmonary Production of Soluble ST2 in Heart Failure.

Publication ,  Journal Article
Pascual-Figal, DA; Pérez-Martínez, MT; Asensio-Lopez, MC; Sanchez-Más, J; García-García, ME; Martinez, CM; Lencina, M; Jara, R; Januzzi, JL; Lax, A
Published in: Circ Heart Fail
December 2018

BACKGROUND: Serum concentrations of ST2 (interleukin-1 receptor-like 1) represent a meaningful prognostic marker in cardiac diseases. Production of soluble ST2 (sST2) may be partially extracardiac. Identification of sST2 sources is relevant to design strategies for modulating its signaling. METHODS AND RESULTS: An experimental model of ischemic heart failure was used. sST2, membrane-bound ST2 (ST2L), and IL-33 were measured in lungs, heart, kidney, and liver by quantifying mRNA and protein expression in tissue samples obtained at different times (1, 2, 4, and 24 weeks). Primary human type II pneumocyte cell cultures were subjected to strain. sST2 was measured in samples of bronchial aspirate and serum obtained from patients treated with invasive respiratory support. In the experimental model, sST2 increased significantly from the first week in both lungs and myocardium, whereas ST2L/IL-33 response was unfavorable in lungs (decrease) and favorable in myocardium (increase). No changes were observed in liver and kidneys. ST2 immunostaining was intensely observed in alveolar epithelium, and sST2 was secreted by primary human type II pneumocytes in response to strain. sST2 levels in lung aspirates were substantially higher in the presence of cardiogenic pulmonary edema (median, 228 [interquartile range, 28.4-324.0] ng/mL; P<0.001) than bronchopneumonia (median, 5.5 [interquartile range, 1.6-6.5]) or neurological disorders (median, 2.9 [interquartile range, 1.7-10.1]), whereas sST2 concentrations in serum did not differ. CONCLUSIONS: The lungs are a relevant source of sST2 in heart failure. These results may have implications for the progression of disease and the development of therapies targeting the ST2 system in patients with heart failure.

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Published In

Circ Heart Fail

DOI

EISSN

1941-3297

Publication Date

December 2018

Volume

11

Issue

12

Start / End Page

e005488

Location

United States

Related Subject Headings

  • Time Factors
  • Receptors, Interleukin-1
  • Rats, Wistar
  • Male
  • Lung
  • Interleukin-33
  • Interleukin-1 Receptor-Like 1 Protein
  • Humans
  • Heart Failure
  • Disease Models, Animal
 

Citation

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Pascual-Figal, D. A., Pérez-Martínez, M. T., Asensio-Lopez, M. C., Sanchez-Más, J., García-García, M. E., Martinez, C. M., … Lax, A. (2018). Pulmonary Production of Soluble ST2 in Heart Failure. Circ Heart Fail, 11(12), e005488. https://doi.org/10.1161/CIRCHEARTFAILURE.118.005488
Pascual-Figal, Domingo A., Maria T. Pérez-Martínez, Maria C. Asensio-Lopez, Jesús Sanchez-Más, Maria E. García-García, Carlos M. Martinez, Miriam Lencina, Ruben Jara, James L. Januzzi, and Antonio Lax. “Pulmonary Production of Soluble ST2 in Heart Failure.Circ Heart Fail 11, no. 12 (December 2018): e005488. https://doi.org/10.1161/CIRCHEARTFAILURE.118.005488.
Pascual-Figal DA, Pérez-Martínez MT, Asensio-Lopez MC, Sanchez-Más J, García-García ME, Martinez CM, et al. Pulmonary Production of Soluble ST2 in Heart Failure. Circ Heart Fail. 2018 Dec;11(12):e005488.
Pascual-Figal, Domingo A., et al. “Pulmonary Production of Soluble ST2 in Heart Failure.Circ Heart Fail, vol. 11, no. 12, Dec. 2018, p. e005488. Pubmed, doi:10.1161/CIRCHEARTFAILURE.118.005488.
Pascual-Figal DA, Pérez-Martínez MT, Asensio-Lopez MC, Sanchez-Más J, García-García ME, Martinez CM, Lencina M, Jara R, Januzzi JL, Lax A. Pulmonary Production of Soluble ST2 in Heart Failure. Circ Heart Fail. 2018 Dec;11(12):e005488.

Published In

Circ Heart Fail

DOI

EISSN

1941-3297

Publication Date

December 2018

Volume

11

Issue

12

Start / End Page

e005488

Location

United States

Related Subject Headings

  • Time Factors
  • Receptors, Interleukin-1
  • Rats, Wistar
  • Male
  • Lung
  • Interleukin-33
  • Interleukin-1 Receptor-Like 1 Protein
  • Humans
  • Heart Failure
  • Disease Models, Animal