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Use of Letermovir as Salvage Therapy for Drug-Resistant Cytomegalovirus Retinitis.

Publication ,  Journal Article
Turner, N; Strand, A; Grewal, DS; Cox, G; Arif, S; Baker, AW; Maziarz, EK; Saullo, JH; Wolfe, CR
Published in: Antimicrob Agents Chemother
March 2019

Treatment options for drug-resistant cytomegalovirus (CMV) are limited. Letermovir is a novel antiviral recently approved for CMV prophylaxis following hematopoietic cell transplantation, but its efficacy in other settings is unknown. We recently used letermovir for salvage treatment in four solid organ transplant recipients with ganciclovir-resistant CMV retinitis. All patients improved clinically without known adverse drug events. However, three patients failed to maintain virologic suppression, including two patients who developed genotypically confirmed resistance to letermovir while on therapy.

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Published In

Antimicrob Agents Chemother

DOI

EISSN

1098-6596

Publication Date

March 2019

Volume

63

Issue

3

Location

United States

Related Subject Headings

  • Transplant Recipients
  • Salvage Therapy
  • Quinazolines
  • Organ Transplantation
  • Microbiology
  • Humans
  • Ganciclovir
  • Drug Resistance, Viral
  • Cytomegalovirus Retinitis
  • Cytomegalovirus
 

Citation

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MLA
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Turner, N., Strand, A., Grewal, D. S., Cox, G., Arif, S., Baker, A. W., … Wolfe, C. R. (2019). Use of Letermovir as Salvage Therapy for Drug-Resistant Cytomegalovirus Retinitis. Antimicrob Agents Chemother, 63(3). https://doi.org/10.1128/AAC.02337-18
Turner, Nicholas, Andrew Strand, Dilraj S. Grewal, Gary Cox, Sana Arif, Arthur W. Baker, Eileen K. Maziarz, Jennifer H. Saullo, and Cameron R. Wolfe. “Use of Letermovir as Salvage Therapy for Drug-Resistant Cytomegalovirus Retinitis.Antimicrob Agents Chemother 63, no. 3 (March 2019). https://doi.org/10.1128/AAC.02337-18.
Turner N, Strand A, Grewal DS, Cox G, Arif S, Baker AW, et al. Use of Letermovir as Salvage Therapy for Drug-Resistant Cytomegalovirus Retinitis. Antimicrob Agents Chemother. 2019 Mar;63(3).
Turner, Nicholas, et al. “Use of Letermovir as Salvage Therapy for Drug-Resistant Cytomegalovirus Retinitis.Antimicrob Agents Chemother, vol. 63, no. 3, Mar. 2019. Pubmed, doi:10.1128/AAC.02337-18.
Turner N, Strand A, Grewal DS, Cox G, Arif S, Baker AW, Maziarz EK, Saullo JH, Wolfe CR. Use of Letermovir as Salvage Therapy for Drug-Resistant Cytomegalovirus Retinitis. Antimicrob Agents Chemother. 2019 Mar;63(3).

Published In

Antimicrob Agents Chemother

DOI

EISSN

1098-6596

Publication Date

March 2019

Volume

63

Issue

3

Location

United States

Related Subject Headings

  • Transplant Recipients
  • Salvage Therapy
  • Quinazolines
  • Organ Transplantation
  • Microbiology
  • Humans
  • Ganciclovir
  • Drug Resistance, Viral
  • Cytomegalovirus Retinitis
  • Cytomegalovirus