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Epidemiology of infection in mechanical circulatory support: A global analysis from the ISHLT Mechanically Assisted Circulatory Support Registry.

Publication ,  Journal Article
Hannan, MM; Xie, R; Cowger, J; Schueler, S; de By, T; Dipchand, AI; Chu, VH; Cantor, RS; Koval, CE; Krabatsch, T; Hayward, CS; Nakatani, T ...
Published in: J Heart Lung Transplant
April 2019

BACKGROUND: Despite advances in device technology and treatment strategies, infection remains a major cause of adverse events (AEs) in mechanical circulatory support (MCS) patients. To characterize the epidemiology of MCS infection, we examined the type, location, and timing of infection in the International Society for Heart and Lung Transplantation Registry (ISHLT) for Mechanically Assisted Circulatory Support (IMACS) over 3 years, 2013 to 2015. METHODS: Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) definitions were used to categorize AE infections occurring in MCS patients within IMACS. The IMACS infection variables were mapped to ISHLT definitions for infection where feasible. Three categories of MCS infection were defined as ventricular assist device (VAD) specific, VAD related, and non-VAD. RESULTS: There were 10,171 patients enrolled from January 2013 through December 2015. Infection was the most common AE, with 3,788 patients (37%) experiencing ≥ 1 infection, and 6,758 AE infections reported overall. Non-VAD infection was the largest category, 4,501: 34.0% pneumonias, 30.6% non-VAD-related bloodstream infections (BSIs), 24.15% urinary tract infections (UTIs), and 10.2% gastrointestinal infections. VAD-specific infection was the second largest category, 1,756: 82.9% driveline, 12.8% pocket, and 4.3% pump/or cannula infections. VAD-related infection was the smallest category, 501: 47.5% BSIs, 47.5% mediastinitis, and 5.0% mediastinitis/pocket infections. All 3 categories were more frequently reported ≤ 3 months after implant. CONCLUSIONS: Non-VAD infection, including pneumonia, BSI, UTI, and gastrointestinal infection, was the leading category of infection in MCS patients and the most frequently reported ≤ 3 months after implant. These results provide evidence to support resourcing and strengthening infection prevention strategy early after implantation in MCS.

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Published In

J Heart Lung Transplant

DOI

EISSN

1557-3117

Publication Date

April 2019

Volume

38

Issue

4

Start / End Page

364 / 373

Location

United States

Related Subject Headings

  • Young Adult
  • Surgery
  • Societies, Medical
  • Registries
  • Prosthesis-Related Infections
  • Middle Aged
  • Male
  • International Cooperation
  • Humans
  • Heart-Lung Transplantation
 

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Hannan, M. M., Xie, R., Cowger, J., Schueler, S., de By, T., Dipchand, A. I., … Kirklin, J. K. (2019). Epidemiology of infection in mechanical circulatory support: A global analysis from the ISHLT Mechanically Assisted Circulatory Support Registry. J Heart Lung Transplant, 38(4), 364–373. https://doi.org/10.1016/j.healun.2019.01.007
Hannan, Margaret M., Rongbing Xie, Jennifer Cowger, Stephan Schueler, Theo de By, Anne I. Dipchand, Vivian H. Chu, et al. “Epidemiology of infection in mechanical circulatory support: A global analysis from the ISHLT Mechanically Assisted Circulatory Support Registry.J Heart Lung Transplant 38, no. 4 (April 2019): 364–73. https://doi.org/10.1016/j.healun.2019.01.007.
Hannan MM, Xie R, Cowger J, Schueler S, de By T, Dipchand AI, et al. Epidemiology of infection in mechanical circulatory support: A global analysis from the ISHLT Mechanically Assisted Circulatory Support Registry. J Heart Lung Transplant. 2019 Apr;38(4):364–73.
Hannan, Margaret M., et al. “Epidemiology of infection in mechanical circulatory support: A global analysis from the ISHLT Mechanically Assisted Circulatory Support Registry.J Heart Lung Transplant, vol. 38, no. 4, Apr. 2019, pp. 364–73. Pubmed, doi:10.1016/j.healun.2019.01.007.
Hannan MM, Xie R, Cowger J, Schueler S, de By T, Dipchand AI, Chu VH, Cantor RS, Koval CE, Krabatsch T, Hayward CS, Nakatani T, Kirklin JK. Epidemiology of infection in mechanical circulatory support: A global analysis from the ISHLT Mechanically Assisted Circulatory Support Registry. J Heart Lung Transplant. 2019 Apr;38(4):364–373.
Journal cover image

Published In

J Heart Lung Transplant

DOI

EISSN

1557-3117

Publication Date

April 2019

Volume

38

Issue

4

Start / End Page

364 / 373

Location

United States

Related Subject Headings

  • Young Adult
  • Surgery
  • Societies, Medical
  • Registries
  • Prosthesis-Related Infections
  • Middle Aged
  • Male
  • International Cooperation
  • Humans
  • Heart-Lung Transplantation