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A Mitochondrial Progesterone Receptor Increases Cardiac Beta-Oxidation and Remodeling.

Publication ,  Journal Article
Dai, Q; Likes, CE; Luz, AL; Mao, L; Yeh, JS; Wei, Z; Kuchibhatla, M; Ilkayeva, OR; Koves, TR; Price, TM
Published in: J Endocr Soc
February 1, 2019

Progesterone is primarily a pregnancy-related hormone, produced in substantial quantities after ovulation and during gestation. Traditionally known to function via nuclear receptors for transcriptional regulation, there is also evidence of nonnuclear action. A previously identified mitochondrial progesterone receptor (PR-M) increases cellular respiration in cell models. In these studies, we demonstrated that expression of PR-M in rat H9c2 cardiomyocytes resulted in a ligand-dependent increase in oxidative cellular respiration and beta-oxidation. Cardiac expression in a TET-On transgenic mouse resulted in gene expression of myofibril proteins for remodeling and proteins involved in oxidative phosphorylation and fatty acid metabolism. In a model of increased afterload from constant transverse aortic constriction, mice expressing PR-M showed a ligand-dependent preservation of cardiac function. From these observations, we propose that PR-M is responsible for progesterone-induced increases in cellular energy production and cardiac remodeling to meet the physiological demands of pregnancy.

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Published In

J Endocr Soc

DOI

EISSN

2472-1972

Publication Date

February 1, 2019

Volume

3

Issue

2

Start / End Page

446 / 467

Location

United States

Related Subject Headings

  • 3201 Cardiovascular medicine and haematology
 

Citation

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Dai, Q., Likes, C. E., Luz, A. L., Mao, L., Yeh, J. S., Wei, Z., … Price, T. M. (2019). A Mitochondrial Progesterone Receptor Increases Cardiac Beta-Oxidation and Remodeling. J Endocr Soc, 3(2), 446–467. https://doi.org/10.1210/js.2018-00219
Dai, Qunsheng, Creighton E. Likes, Anthony L. Luz, Lan Mao, Jason S. Yeh, Zhengzheng Wei, Maragatha Kuchibhatla, Olga R. Ilkayeva, Timothy R. Koves, and Thomas M. Price. “A Mitochondrial Progesterone Receptor Increases Cardiac Beta-Oxidation and Remodeling.J Endocr Soc 3, no. 2 (February 1, 2019): 446–67. https://doi.org/10.1210/js.2018-00219.
Dai Q, Likes CE, Luz AL, Mao L, Yeh JS, Wei Z, et al. A Mitochondrial Progesterone Receptor Increases Cardiac Beta-Oxidation and Remodeling. J Endocr Soc. 2019 Feb 1;3(2):446–67.
Dai, Qunsheng, et al. “A Mitochondrial Progesterone Receptor Increases Cardiac Beta-Oxidation and Remodeling.J Endocr Soc, vol. 3, no. 2, Feb. 2019, pp. 446–67. Pubmed, doi:10.1210/js.2018-00219.
Dai Q, Likes CE, Luz AL, Mao L, Yeh JS, Wei Z, Kuchibhatla M, Ilkayeva OR, Koves TR, Price TM. A Mitochondrial Progesterone Receptor Increases Cardiac Beta-Oxidation and Remodeling. J Endocr Soc. 2019 Feb 1;3(2):446–467.
Journal cover image

Published In

J Endocr Soc

DOI

EISSN

2472-1972

Publication Date

February 1, 2019

Volume

3

Issue

2

Start / End Page

446 / 467

Location

United States

Related Subject Headings

  • 3201 Cardiovascular medicine and haematology