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Challenges to curing primary brain tumours.

Publication ,  Journal Article
Aldape, K; Brindle, KM; Chesler, L; Chopra, R; Gajjar, A; Gilbert, MR; Gottardo, N; Gutmann, DH; Hargrave, D; Holland, EC; Jones, DTW ...
Published in: Nat Rev Clin Oncol
August 2019

Despite decades of research, brain tumours remain among the deadliest of all forms of cancer. The ability of these tumours to resist almost all conventional and novel treatments relates, in part, to the unique cell-intrinsic and microenvironmental properties of neural tissues. In an attempt to encourage progress in our understanding and ability to successfully treat patients with brain tumours, Cancer Research UK convened an international panel of clinicians and laboratory-based scientists to identify challenges that must be overcome if we are to cure all patients with a brain tumour. The seven key challenges summarized in this Position Paper are intended to serve as foci for future research and investment.

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Published In

Nat Rev Clin Oncol

DOI

EISSN

1759-4782

Publication Date

August 2019

Volume

16

Issue

8

Start / End Page

509 / 520

Location

England

Related Subject Headings

  • Humans
  • Brain Neoplasms
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

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Aldape, K., Brindle, K. M., Chesler, L., Chopra, R., Gajjar, A., Gilbert, M. R., … Gilbertson, R. J. (2019). Challenges to curing primary brain tumours. Nat Rev Clin Oncol, 16(8), 509–520. https://doi.org/10.1038/s41571-019-0177-5
Aldape, Kenneth, Kevin M. Brindle, Louis Chesler, Rajesh Chopra, Amar Gajjar, Mark R. Gilbert, Nicholas Gottardo, et al. “Challenges to curing primary brain tumours.Nat Rev Clin Oncol 16, no. 8 (August 2019): 509–20. https://doi.org/10.1038/s41571-019-0177-5.
Aldape K, Brindle KM, Chesler L, Chopra R, Gajjar A, Gilbert MR, et al. Challenges to curing primary brain tumours. Nat Rev Clin Oncol. 2019 Aug;16(8):509–20.
Aldape, Kenneth, et al. “Challenges to curing primary brain tumours.Nat Rev Clin Oncol, vol. 16, no. 8, Aug. 2019, pp. 509–20. Pubmed, doi:10.1038/s41571-019-0177-5.
Aldape K, Brindle KM, Chesler L, Chopra R, Gajjar A, Gilbert MR, Gottardo N, Gutmann DH, Hargrave D, Holland EC, Jones DTW, Joyce JA, Kearns P, Kieran MW, Mellinghoff IK, Merchant M, Pfister SM, Pollard SM, Ramaswamy V, Rich JN, Robinson GW, Rowitch DH, Sampson JH, Taylor MD, Workman P, Gilbertson RJ. Challenges to curing primary brain tumours. Nat Rev Clin Oncol. 2019 Aug;16(8):509–520.

Published In

Nat Rev Clin Oncol

DOI

EISSN

1759-4782

Publication Date

August 2019

Volume

16

Issue

8

Start / End Page

509 / 520

Location

England

Related Subject Headings

  • Humans
  • Brain Neoplasms
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis