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Aspirin for primary prevention of cardiovascular outcomes in diabetes mellitus: An updated systematic review and meta-analysis.

Publication ,  Journal Article
Khan, SU; Ul Abideen Asad, Z; Khan, MU; Talluri, S; Ali, F; Shahzeb Khan, M; Lone, AN; Mookadam, F; Krasuski, RA; Kaluski, E
Published in: Eur J Prev Cardiol
December 2020

BACKGROUND: The safety and efficacy of aspirin for the primary prevention of cardiovascular disease in patients with diabetes mellitus remains controversial. DESIGN: A meta-analysis to investigate the effects of aspirin for the prevention of cardiovascular disease in diabetes mellitus. METHODS: Ten randomized controlled trials were selected using MEDLINE, EMBASE and CENTRAL databases until 27 September 2018. Risk ratios (RRs) with 95% confidence intervals (CIs) and risk differences (RDs) reported as incident events per 1000 person-years were calculated. RESULTS: In 33,679 patients, aspirin did not significantly reduce the risk of major adverse cardiovascular outcomes (RR 0.93, 95% CI 0.87-1.00, P = 0.06; RD -0.68 incident cases per 1000 person-years (95% CI -1.54, 0.17)), cardiovascular mortality (RR 0.95, 95% CI 0.83-1.09, P = 0.49; RD 0.11 incident cases per 1000 person-years (95% CI -0.80, 1.02)), myocardial infarction (RR 0.91, 95% CI 0.75-1.11, P = 0.36; RD -0.66 incident cases per 1000 person-years (95% CI -2.07, 0.75)), or stroke (RR 0.91, 95% C, 0.76-1.10, P = 0.33; RD -0.55 incident cases per 1000 person-years (95% CI -1.57, 0.47)). There was a significantly higher risk of total bleeding associated with aspirin (RR 1.29, 95% CI 1.07-1.55, P = 0.01; RD 1.49 incident cases per 1000 person-years (95% CI 0.36, 2.61)). CONCLUSION: The use of aspirin for primary prevention of cardiovascular disease in patients with diabetes mellitus increases the risk of total bleeding without reducing the risk of major adverse cardiovascular outcomes.

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Published In

Eur J Prev Cardiol

DOI

EISSN

2047-4881

Publication Date

December 2020

Volume

27

Issue

19

Start / End Page

2034 / 2041

Location

England

Related Subject Headings

  • Primary Prevention
  • Platelet Aggregation Inhibitors
  • Humans
  • Diabetic Angiopathies
  • Diabetes Mellitus
  • Cardiovascular System & Hematology
  • Cardiovascular Diseases
  • Aspirin
  • 1103 Clinical Sciences
  • 1102 Cardiorespiratory Medicine and Haematology
 

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Khan, S. U., Ul Abideen Asad, Z., Khan, M. U., Talluri, S., Ali, F., Shahzeb Khan, M., … Kaluski, E. (2020). Aspirin for primary prevention of cardiovascular outcomes in diabetes mellitus: An updated systematic review and meta-analysis. Eur J Prev Cardiol, 27(19), 2034–2041. https://doi.org/10.1177/2047487319825510
Khan, Safi U., Zain Ul Abideen Asad, Muhammad U. Khan, Swapna Talluri, Farman Ali, Muhammad Shahzeb Khan, Ahmad N. Lone, Farouk Mookadam, Richard A. Krasuski, and Edo Kaluski. “Aspirin for primary prevention of cardiovascular outcomes in diabetes mellitus: An updated systematic review and meta-analysis.Eur J Prev Cardiol 27, no. 19 (December 2020): 2034–41. https://doi.org/10.1177/2047487319825510.
Khan SU, Ul Abideen Asad Z, Khan MU, Talluri S, Ali F, Shahzeb Khan M, et al. Aspirin for primary prevention of cardiovascular outcomes in diabetes mellitus: An updated systematic review and meta-analysis. Eur J Prev Cardiol. 2020 Dec;27(19):2034–41.
Khan, Safi U., et al. “Aspirin for primary prevention of cardiovascular outcomes in diabetes mellitus: An updated systematic review and meta-analysis.Eur J Prev Cardiol, vol. 27, no. 19, Dec. 2020, pp. 2034–41. Pubmed, doi:10.1177/2047487319825510.
Khan SU, Ul Abideen Asad Z, Khan MU, Talluri S, Ali F, Shahzeb Khan M, Lone AN, Mookadam F, Krasuski RA, Kaluski E. Aspirin for primary prevention of cardiovascular outcomes in diabetes mellitus: An updated systematic review and meta-analysis. Eur J Prev Cardiol. 2020 Dec;27(19):2034–2041.
Journal cover image

Published In

Eur J Prev Cardiol

DOI

EISSN

2047-4881

Publication Date

December 2020

Volume

27

Issue

19

Start / End Page

2034 / 2041

Location

England

Related Subject Headings

  • Primary Prevention
  • Platelet Aggregation Inhibitors
  • Humans
  • Diabetic Angiopathies
  • Diabetes Mellitus
  • Cardiovascular System & Hematology
  • Cardiovascular Diseases
  • Aspirin
  • 1103 Clinical Sciences
  • 1102 Cardiorespiratory Medicine and Haematology