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A δ Homolog for Dementia Case Finding with Replication in the Alzheimer's Disease Neuroimaging Initiative.

Publication ,  Journal Article
Royall, DR; Palmer, RF; Alzheimer’s Disease Neuroimaging Initiative,
Published in: J Alzheimers Dis
2019

Dementia can be empirically described by the latent dementia phenotype "δ" and its various composite "homologs". We have explored δ's blood-based protein biomarkers in the Texas Alzheimer's Research and Care Consortium (TARCC) study. However, it would be convenient to replicate those associations in the Alzheimer's Disease Neuroimaging Initiative (ADNI). To this end, we have engineered a δ homolog from observed cognitive performance measures common to both projects. Our findings were replicated in randomly selected 50% splits of TARCC data (Group 1, N = 1,747; Group 2, N = 1,755), and then independently in ADNI (N = 1,737). The new δ homolog, i.e., "dT2A" (d-TARCC to ADNI), fit the data of both studies well, and was strongly correlated with dementia severity, as rated by the Clinical Dementia Rating Scale "sum of boxes" (TARCC: r = 0.99, p < 0.001; ADNI: r = 0.96, p < 0.001). dT2A achieved an area under the receiver operating characteristic curve of 0.981 (0.976-0.985) for the discrimination of Alzheimer's disease from normal controls in TARCC, and 0.988 (0.983-0.993) in ADNI. dT2A is the 12th δ homolog published to date, and opens the door to independent replications across these and similar studies.

Duke Scholars

Published In

J Alzheimers Dis

DOI

EISSN

1875-8908

Publication Date

2019

Volume

67

Issue

1

Start / End Page

67 / 79

Location

Netherlands

Related Subject Headings

  • Texas
  • Psychomotor Performance
  • Psychiatric Status Rating Scales
  • Neuropsychological Tests
  • Neurology & Neurosurgery
  • Neuroimaging
  • Male
  • Intelligence Tests
  • Humans
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Royall, D. R., Palmer, R. F., & Alzheimer’s Disease Neuroimaging Initiative, . (2019). A δ Homolog for Dementia Case Finding with Replication in the Alzheimer's Disease Neuroimaging Initiative. J Alzheimers Dis, 67(1), 67–79. https://doi.org/10.3233/JAD-171053
Royall, Donald R., Raymond F. Palmer, and Raymond F. Alzheimer’s Disease Neuroimaging Initiative. “A δ Homolog for Dementia Case Finding with Replication in the Alzheimer's Disease Neuroimaging Initiative.J Alzheimers Dis 67, no. 1 (2019): 67–79. https://doi.org/10.3233/JAD-171053.
Royall DR, Palmer RF, Alzheimer’s Disease Neuroimaging Initiative. A δ Homolog for Dementia Case Finding with Replication in the Alzheimer's Disease Neuroimaging Initiative. J Alzheimers Dis. 2019;67(1):67–79.
Royall, Donald R., et al. “A δ Homolog for Dementia Case Finding with Replication in the Alzheimer's Disease Neuroimaging Initiative.J Alzheimers Dis, vol. 67, no. 1, 2019, pp. 67–79. Pubmed, doi:10.3233/JAD-171053.
Royall DR, Palmer RF, Alzheimer’s Disease Neuroimaging Initiative. A δ Homolog for Dementia Case Finding with Replication in the Alzheimer's Disease Neuroimaging Initiative. J Alzheimers Dis. 2019;67(1):67–79.

Published In

J Alzheimers Dis

DOI

EISSN

1875-8908

Publication Date

2019

Volume

67

Issue

1

Start / End Page

67 / 79

Location

Netherlands

Related Subject Headings

  • Texas
  • Psychomotor Performance
  • Psychiatric Status Rating Scales
  • Neuropsychological Tests
  • Neurology & Neurosurgery
  • Neuroimaging
  • Male
  • Intelligence Tests
  • Humans
  • Female