Skip to main content
Journal cover image

Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals.

Publication ,  Journal Article
Henry, C; Zheng, N-Y; Huang, M; Cabanov, A; Rojas, KT; Kaur, K; Andrews, SF; Palm, A-KE; Chen, Y-Q; Li, Y; Hoskova, K; Utset, HA; Vieira, MC ...
Published in: Cell Host Microbe
March 13, 2019

Influenza is a leading cause of death in the elderly, and the vaccine protects only a fraction of this population. A key aspect of antibody-mediated anti-influenza virus immunity is adaptation to antigenically distinct epitopes on emerging strains. We examined factors contributing to reduced influenza vaccine efficacy in the elderly and uncovered a dramatic reduction in the accumulation of de novo immunoglobulin gene somatic mutations upon vaccination. This reduction is associated with a significant decrease in the capacity of antibodies to target the viral glycoprotein, hemagglutinin (HA), and critical protective epitopes surrounding the HA receptor-binding domain. Immune escape by antigenic drift, in which viruses generate mutations in key antigenic epitopes, becomes highly exaggerated. Because of this reduced adaptability, most B cells activated in the elderly cohort target highly conserved but less potent epitopes. Given these findings, vaccines driving immunoglobulin gene somatic hypermutation should be a priority to protect elderly individuals.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Cell Host Microbe

DOI

EISSN

1934-6069

Publication Date

March 13, 2019

Volume

25

Issue

3

Start / End Page

357 / 366.e6

Location

United States

Related Subject Headings

  • Young Adult
  • Orthomyxoviridae
  • Mutation
  • Middle Aged
  • Influenza Vaccines
  • Immunology
  • Immunity, Humoral
  • Humans
  • Healthy Volunteers
  • Epitopes
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Henry, C., Zheng, N.-Y., Huang, M., Cabanov, A., Rojas, K. T., Kaur, K., … Wilson, P. C. (2019). Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals. Cell Host Microbe, 25(3), 357-366.e6. https://doi.org/10.1016/j.chom.2019.01.002
Henry, Carole, Nai-Ying Zheng, Min Huang, Alexandra Cabanov, Karla Thatcher Rojas, Kaval Kaur, Sarah F. Andrews, et al. “Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals.Cell Host Microbe 25, no. 3 (March 13, 2019): 357-366.e6. https://doi.org/10.1016/j.chom.2019.01.002.
Henry C, Zheng N-Y, Huang M, Cabanov A, Rojas KT, Kaur K, et al. Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals. Cell Host Microbe. 2019 Mar 13;25(3):357-366.e6.
Henry, Carole, et al. “Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals.Cell Host Microbe, vol. 25, no. 3, Mar. 2019, pp. 357-366.e6. Pubmed, doi:10.1016/j.chom.2019.01.002.
Henry C, Zheng N-Y, Huang M, Cabanov A, Rojas KT, Kaur K, Andrews SF, Palm A-KE, Chen Y-Q, Li Y, Hoskova K, Utset HA, Vieira MC, Wrammert J, Ahmed R, Holden-Wiltse J, Topham DJ, Treanor JJ, Ertl HC, Schmader KE, Cobey S, Krammer F, Hensley SE, Greenberg H, He X-S, Wilson PC. Influenza Virus Vaccination Elicits Poorly Adapted B Cell Responses in Elderly Individuals. Cell Host Microbe. 2019 Mar 13;25(3):357-366.e6.
Journal cover image

Published In

Cell Host Microbe

DOI

EISSN

1934-6069

Publication Date

March 13, 2019

Volume

25

Issue

3

Start / End Page

357 / 366.e6

Location

United States

Related Subject Headings

  • Young Adult
  • Orthomyxoviridae
  • Mutation
  • Middle Aged
  • Influenza Vaccines
  • Immunology
  • Immunity, Humoral
  • Humans
  • Healthy Volunteers
  • Epitopes