CDKN2A/B Loss Is Associated with Anaplastic Transformation in a Case of NTRK2 Fusion-positive Pilocytic Astrocytoma.
Publication
, Journal Article
López, GY; Perry, A; Harding, B; Li, M; Santi, M
Published in: Neuropathol Appl Neurobiol
February 2019
Pilocytic astrocytomas are typically grade I astrocytomas, only rarely progressing to anaplastic counterparts [1]. In the case of anaplastic pilocytic astrocytomas, some are associated with neurofibromatosis type 1 (NF1) [2], others are associated with radiation treatment [2], and the remainder appear de novo. These de novo tumours can be particularly challenging to distinguish from glioblastomas, which are grade IV and carry a worse prognosis. Here we report an unusual case of malignant transformation of a pilocytic astrocytoma in the absence of NF1 alterations or radiation treatment.
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Published In
Neuropathol Appl Neurobiol
DOI
EISSN
1365-2990
Publication Date
February 2019
Volume
45
Issue
2
Start / End Page
174 / 178
Location
England
Related Subject Headings
- Receptor, trkB
- Neurology & Neurosurgery
- Membrane Glycoproteins
- Humans
- Female
- Cyclin-Dependent Kinase Inhibitor p16
- Cyclin-Dependent Kinase Inhibitor p15
- Child, Preschool
- Brain Neoplasms
- Brain
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López, G. Y., Perry, A., Harding, B., Li, M., & Santi, M. (2019). CDKN2A/B Loss Is Associated with Anaplastic Transformation in a Case of NTRK2 Fusion-positive Pilocytic Astrocytoma. Neuropathol Appl Neurobiol, 45(2), 174–178. https://doi.org/10.1111/nan.12503
López, G. Y., A. Perry, B. Harding, M. Li, and M. Santi. “CDKN2A/B Loss Is Associated with Anaplastic Transformation in a Case of NTRK2 Fusion-positive Pilocytic Astrocytoma.” Neuropathol Appl Neurobiol 45, no. 2 (February 2019): 174–78. https://doi.org/10.1111/nan.12503.
López GY, Perry A, Harding B, Li M, Santi M. CDKN2A/B Loss Is Associated with Anaplastic Transformation in a Case of NTRK2 Fusion-positive Pilocytic Astrocytoma. Neuropathol Appl Neurobiol. 2019 Feb;45(2):174–8.
López, G. Y., et al. “CDKN2A/B Loss Is Associated with Anaplastic Transformation in a Case of NTRK2 Fusion-positive Pilocytic Astrocytoma.” Neuropathol Appl Neurobiol, vol. 45, no. 2, Feb. 2019, pp. 174–78. Pubmed, doi:10.1111/nan.12503.
López GY, Perry A, Harding B, Li M, Santi M. CDKN2A/B Loss Is Associated with Anaplastic Transformation in a Case of NTRK2 Fusion-positive Pilocytic Astrocytoma. Neuropathol Appl Neurobiol. 2019 Feb;45(2):174–178.
Published In
Neuropathol Appl Neurobiol
DOI
EISSN
1365-2990
Publication Date
February 2019
Volume
45
Issue
2
Start / End Page
174 / 178
Location
England
Related Subject Headings
- Receptor, trkB
- Neurology & Neurosurgery
- Membrane Glycoproteins
- Humans
- Female
- Cyclin-Dependent Kinase Inhibitor p16
- Cyclin-Dependent Kinase Inhibitor p15
- Child, Preschool
- Brain Neoplasms
- Brain