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The Relationship Between Hippocampal Volumes and Delayed Recall Is Modified by APOE ε4 in Mild Cognitive Impairment.

Publication ,  Journal Article
Wang, X; Zhou, W; Ye, T; Lin, X; Zhang, J; Alzheimer’s Disease Neuroimaging Initiative,
Published in: Front Aging Neurosci
2019

Objective: To investigate whether APOE ε4 affects the association of verbal memory with neurodegeneration presented by the hippocampal volume/intracranial volume ratio (HpVR). Methods: The study sample included 371 individuals with normal cognition (NC), 725 subjects with amnestic mild cognitive impairment (aMCI), and 251 patients with mild Alzheimer's disease (AD) from the Alzheimer's Disease Neuroimaging Initiative (ADNI) who underwent the rey auditory verbal learning test (RAVLT). Multiple linear regression models were conducted to assess the effect of the APOE ε4∗HpVR interaction on RAVLT in all subjects and in each diagnostic group adjusting for age, gender and educational attainment, and global cognition. Results: In all subjects, there was no significant APOE ε4 × HpVR interaction for immediate recall or delayed recall (p > 0.05). However, in aMCI subjects, there was a significant APOE ε4 × HpVR interaction for delayed recall (p = 0.008), but not immediate recall (p = 0.15). More specifically, the detrimental effect of APOE ε4 on delayed recall altered by HpVR such that this effect was most evident among subjects with small to moderate HpVR, but this disadvantage was absent or even reversed among subjects with larger HpVR. No significant interaction was observed in the NC or AD group. Conclusion: These findings highlight a potential role of APOE ε4 status in affecting the association of hippocampus size with delayed recall memory in the early stage of AD.

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Published In

Front Aging Neurosci

DOI

ISSN

1663-4365

Publication Date

2019

Volume

11

Start / End Page

36

Location

Switzerland

Related Subject Headings

  • 5202 Biological psychology
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
  • 1109 Neurosciences
  • 0601 Biochemistry and Cell Biology
 

Citation

APA
Chicago
ICMJE
MLA
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Wang, X., Zhou, W., Ye, T., Lin, X., Zhang, J., & Alzheimer’s Disease Neuroimaging Initiative, . (2019). The Relationship Between Hippocampal Volumes and Delayed Recall Is Modified by APOE ε4 in Mild Cognitive Impairment. Front Aging Neurosci, 11, 36. https://doi.org/10.3389/fnagi.2019.00036
Wang, Xiwu, Wenjun Zhou, Teng Ye, Xiaodong Lin, Jie Zhang, and Jie Alzheimer’s Disease Neuroimaging Initiative. “The Relationship Between Hippocampal Volumes and Delayed Recall Is Modified by APOE ε4 in Mild Cognitive Impairment.Front Aging Neurosci 11 (2019): 36. https://doi.org/10.3389/fnagi.2019.00036.
Wang X, Zhou W, Ye T, Lin X, Zhang J, Alzheimer’s Disease Neuroimaging Initiative. The Relationship Between Hippocampal Volumes and Delayed Recall Is Modified by APOE ε4 in Mild Cognitive Impairment. Front Aging Neurosci. 2019;11:36.
Wang, Xiwu, et al. “The Relationship Between Hippocampal Volumes and Delayed Recall Is Modified by APOE ε4 in Mild Cognitive Impairment.Front Aging Neurosci, vol. 11, 2019, p. 36. Pubmed, doi:10.3389/fnagi.2019.00036.
Wang X, Zhou W, Ye T, Lin X, Zhang J, Alzheimer’s Disease Neuroimaging Initiative. The Relationship Between Hippocampal Volumes and Delayed Recall Is Modified by APOE ε4 in Mild Cognitive Impairment. Front Aging Neurosci. 2019;11:36.

Published In

Front Aging Neurosci

DOI

ISSN

1663-4365

Publication Date

2019

Volume

11

Start / End Page

36

Location

Switzerland

Related Subject Headings

  • 5202 Biological psychology
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
  • 1109 Neurosciences
  • 0601 Biochemistry and Cell Biology