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A Multi-study Coordinated Meta-analysis of Pulmonary Function and Cognition in Aging.

Publication ,  Journal Article
Duggan, EC; Piccinin, AM; Clouston, S; Koval, AV; Robitaille, A; Zammit, AR; Wu, C; Brown, CL; Lee, LO; Finkel, D; Beasley, WH; Kaye, J ...
Published in: The journals of gerontology. Series A, Biological sciences and medical sciences
October 2019

Substantial research is dedicated to understanding the aging-related dynamics among individual differences in level, change, and variation across physical and cognitive abilities. Evaluating replicability and synthesizing these findings has been limited by differences in measurements and samples, and by study design and statistical analyses confounding between-person differences with within-person changes. In this article, we conducted a coordinated analysis and summary meta-analysis of new results on the aging-related dynamics linking pulmonary function and cognitive performance.We performed coordinated analysis of bivariate growth models in data from 20,586 participants across eight longitudinal studies to examine individual differences in baseline level, rate of change, and occasion-specific variability in pulmonary and cognitive functioning. Results were summarized using meta-analysis.We found consistent but weak baseline and longitudinal associations in levels of pulmonary and cognitive functioning, but no associations in occasion-specific variability.Results provide limited evidence for a consistent link between simultaneous changes in pulmonary and cognitive function in a normal aging population. Further research is required to understand patterns of onset of decline and differences in rates of change within and across physical and cognitive functioning domains, both within-individuals and across countries and birth cohorts. Coordinated analysis provides an efficient and rigorous approach for replicating and comparing results across independent longitudinal studies.

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Published In

The journals of gerontology. Series A, Biological sciences and medical sciences

DOI

EISSN

1758-535X

ISSN

1079-5006

Publication Date

October 2019

Volume

74

Issue

11

Start / End Page

1793 / 1804

Related Subject Headings

  • Vital Capacity
  • Sex Factors
  • Risk Assessment
  • Respiratory Function Tests
  • Prognosis
  • Prevalence
  • Neuropsychological Tests
  • Middle Aged
  • Male
  • Lung Volume Measurements
 

Citation

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Duggan, E. C., Piccinin, A. M., Clouston, S., Koval, A. V., Robitaille, A., Zammit, A. R., … Hofer, S. M. (2019). A Multi-study Coordinated Meta-analysis of Pulmonary Function and Cognition in Aging. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 74(11), 1793–1804. https://doi.org/10.1093/gerona/glz057
Duggan, Emily C., Andrea M. Piccinin, Sean Clouston, Andriy V. Koval, Annie Robitaille, Andrea R. Zammit, Chenkai Wu, et al. “A Multi-study Coordinated Meta-analysis of Pulmonary Function and Cognition in Aging.The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 74, no. 11 (October 2019): 1793–1804. https://doi.org/10.1093/gerona/glz057.
Duggan EC, Piccinin AM, Clouston S, Koval AV, Robitaille A, Zammit AR, et al. A Multi-study Coordinated Meta-analysis of Pulmonary Function and Cognition in Aging. The journals of gerontology Series A, Biological sciences and medical sciences. 2019 Oct;74(11):1793–804.
Duggan, Emily C., et al. “A Multi-study Coordinated Meta-analysis of Pulmonary Function and Cognition in Aging.The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 74, no. 11, Oct. 2019, pp. 1793–804. Epmc, doi:10.1093/gerona/glz057.
Duggan EC, Piccinin AM, Clouston S, Koval AV, Robitaille A, Zammit AR, Wu C, Brown CL, Lee LO, Finkel D, Beasley WH, Kaye J, Terrera GM, Katz M, Lipton RB, Deeg D, Bennett DA, Praetorius Björk M, Johansson B, Spiro A, Weuve J, Hofer SM. A Multi-study Coordinated Meta-analysis of Pulmonary Function and Cognition in Aging. The journals of gerontology Series A, Biological sciences and medical sciences. 2019 Oct;74(11):1793–1804.
Journal cover image

Published In

The journals of gerontology. Series A, Biological sciences and medical sciences

DOI

EISSN

1758-535X

ISSN

1079-5006

Publication Date

October 2019

Volume

74

Issue

11

Start / End Page

1793 / 1804

Related Subject Headings

  • Vital Capacity
  • Sex Factors
  • Risk Assessment
  • Respiratory Function Tests
  • Prognosis
  • Prevalence
  • Neuropsychological Tests
  • Middle Aged
  • Male
  • Lung Volume Measurements