Skip to main content

Associations of physical activity with survival and progression in metastatic colorectal cancer: Results from CALGB 80405 (Alliance).

Publication ,  Conference
Guercio, BJ; Venook, AP; Niedzwiecki, D; Zhang, S; Sato, K; Fuchs, CS; Lenz, H-J; Innocenti, F; Fruth, B; Van Blarigan, E; O'Neil, BH ...
Published in: Journal of Clinical Oncology
February 1, 2017

659 Background: Regular physical activity (PA) is associated with reduced risk of recurrence and mortality in non-metastatic colorectal cancer. Its influence on patients with metastatic colorectal cancer (mCRC) is largely unexplored. Methods: 1231 patients participating in CALGB 80405 (first-line phase III chemotherapy trial for mCRC) completed questionnaires that included self-report on PA at time of chemotherapy initiation and total metabolic equivalent task (MET)-hours/week were determined based on responses. The primary endpoint of the clinical trial and this companion study was overall survival (OS), with progression-free survival (PFS) as a secondary endpoint. To minimize confounding by poor and rapidly declining health, we excluded patients who experienced progression or died within 60 days of activity assessment and adjusted for known prognostic factors, comorbid illness, and weight loss over the previous six months. Results: Compared with patients engaged in less than three MET-hours/week of PA, patients engaged in 18 or more MET-hours/week experienced an adjusted hazard ratio for OS of 0.81 (95% CI 0.67 to 0.98, P for trend 0.03) and for PFS of 0.84 (95% CI 0.71 to 1.00, P for trend 0.03). Greater nonvigorous PA and walking duration were both associated with improved OS ( P for trend 0.01 and 0.04, respectively). Conclusions: In mCRC patients from CALGB 80405, greater total PA was associated with improved PFS and OS, while greater walking duration and non-vigorous PA were associated with reduced risk of all-cause mortality. Support: U10CA180821, U10CA180882. ClinicalTrials.gov ID: NCT00265850 [Table: see text]

Duke Scholars

Published In

Journal of Clinical Oncology

DOI

EISSN

1527-7755

ISSN

0732-183X

Publication Date

February 1, 2017

Volume

35

Issue

4_suppl

Start / End Page

659 / 659

Publisher

American Society of Clinical Oncology (ASCO)

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Guercio, B. J., Venook, A. P., Niedzwiecki, D., Zhang, S., Sato, K., Fuchs, C. S., … Meyerhardt, J. A. (2017). Associations of physical activity with survival and progression in metastatic colorectal cancer: Results from CALGB 80405 (Alliance). In Journal of Clinical Oncology (Vol. 35, pp. 659–659). American Society of Clinical Oncology (ASCO). https://doi.org/10.1200/jco.2017.35.4_suppl.659
Guercio, Brendan John, Alan P. Venook, Donna Niedzwiecki, Sui Zhang, Kaori Sato, Charles S. Fuchs, Heinz-Josef Lenz, et al. “Associations of physical activity with survival and progression in metastatic colorectal cancer: Results from CALGB 80405 (Alliance).” In Journal of Clinical Oncology, 35:659–659. American Society of Clinical Oncology (ASCO), 2017. https://doi.org/10.1200/jco.2017.35.4_suppl.659.
Guercio BJ, Venook AP, Niedzwiecki D, Zhang S, Sato K, Fuchs CS, et al. Associations of physical activity with survival and progression in metastatic colorectal cancer: Results from CALGB 80405 (Alliance). In: Journal of Clinical Oncology. American Society of Clinical Oncology (ASCO); 2017. p. 659–659.
Guercio, Brendan John, et al. “Associations of physical activity with survival and progression in metastatic colorectal cancer: Results from CALGB 80405 (Alliance).Journal of Clinical Oncology, vol. 35, no. 4_suppl, American Society of Clinical Oncology (ASCO), 2017, pp. 659–659. Crossref, doi:10.1200/jco.2017.35.4_suppl.659.
Guercio BJ, Venook AP, Niedzwiecki D, Zhang S, Sato K, Fuchs CS, Lenz H-J, Innocenti F, Fruth B, Van Blarigan E, O’Neil BH, Shaw JE, Polite BN, Hochster HS, Atkins JN, Goldberg RM, Mayer RJ, Bertagnolli MM, Blanke CD, Meyerhardt JA. Associations of physical activity with survival and progression in metastatic colorectal cancer: Results from CALGB 80405 (Alliance). Journal of Clinical Oncology. American Society of Clinical Oncology (ASCO); 2017. p. 659–659.

Published In

Journal of Clinical Oncology

DOI

EISSN

1527-7755

ISSN

0732-183X

Publication Date

February 1, 2017

Volume

35

Issue

4_suppl

Start / End Page

659 / 659

Publisher

American Society of Clinical Oncology (ASCO)

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
  • 1103 Clinical Sciences