In vitro generation of renal tubular epithelial cells from fibroblasts: implications for precision and regenerative medicine in nephrology.
Publication
, Journal Article
Wyatt, CM; Dubois, N
Published in: Kidney Int
February 2017
Prior efforts to generate renal epithelial cells in vitro have relied on pluripotent or bone marrow-derived mesenchymal stem cells. A recent publication in Nature Cell Biology describes the generation of induced tubular epithelial cells from fibroblasts, potentially offering a novel platform for personalized drug toxicity screening and in vitro disease modeling. This report serves as a promising proof of principle study and opens future research directions, including the optimization of the reprogramming process, efficient translation to adult human fibroblasts, and the generation of highly specific functional renal cell types.
Duke Scholars
Published In
Kidney Int
DOI
EISSN
1523-1755
Publication Date
February 2017
Volume
91
Issue
2
Start / End Page
265 / 267
Location
United States
Related Subject Headings
- Urology & Nephrology
- Tissue Engineering
- Regenerative Medicine
- Precision Medicine
- Phenotype
- Nephrology
- Mice
- Kidney Tubules
- Humans
- Gene Expression Regulation, Developmental
Citation
APA
Chicago
ICMJE
MLA
NLM
Wyatt, C. M., & Dubois, N. (2017). In vitro generation of renal tubular epithelial cells from fibroblasts: implications for precision and regenerative medicine in nephrology. Kidney Int, 91(2), 265–267. https://doi.org/10.1016/j.kint.2016.12.003
Wyatt, Christina M., and Nicole Dubois. “In vitro generation of renal tubular epithelial cells from fibroblasts: implications for precision and regenerative medicine in nephrology.” Kidney Int 91, no. 2 (February 2017): 265–67. https://doi.org/10.1016/j.kint.2016.12.003.
Wyatt CM, Dubois N. In vitro generation of renal tubular epithelial cells from fibroblasts: implications for precision and regenerative medicine in nephrology. Kidney Int. 2017 Feb;91(2):265–7.
Wyatt, Christina M., and Nicole Dubois. “In vitro generation of renal tubular epithelial cells from fibroblasts: implications for precision and regenerative medicine in nephrology.” Kidney Int, vol. 91, no. 2, Feb. 2017, pp. 265–67. Pubmed, doi:10.1016/j.kint.2016.12.003.
Wyatt CM, Dubois N. In vitro generation of renal tubular epithelial cells from fibroblasts: implications for precision and regenerative medicine in nephrology. Kidney Int. 2017 Feb;91(2):265–267.
Published In
Kidney Int
DOI
EISSN
1523-1755
Publication Date
February 2017
Volume
91
Issue
2
Start / End Page
265 / 267
Location
United States
Related Subject Headings
- Urology & Nephrology
- Tissue Engineering
- Regenerative Medicine
- Precision Medicine
- Phenotype
- Nephrology
- Mice
- Kidney Tubules
- Humans
- Gene Expression Regulation, Developmental