Urine processing impacts uric acid level in HIV-infected adults: implications for diagnosing tenofovir-associated proximal tubulopathy.
Publication
, Journal Article
Hotta, MT; Broderick, E; Wyatt, CM
Published in: AIDS
July 17, 2013
Urine specimens are valuable to investigate kidney disease and antiretroviral nephrotoxicity. We observed large rust-colored pellets in some urine specimens after overnight storage at 4°C. Testing of supernatant under varying conditions demonstrated that this phenomenon reflects supersaturation and precipitation of uric acid in samples with high uric acid concentration. Delays in processing, even with refrigeration, may decrease the sensitivity of urine uric acid testing, with implications for the evaluation of proximal tubulopathy related to tenofovir.
Duke Scholars
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Published In
AIDS
DOI
EISSN
1473-5571
Publication Date
July 17, 2013
Volume
27
Issue
11
Start / End Page
1827 / 1829
Location
England
Related Subject Headings
- Virology
- Uric Acid
- Time Factors
- Tenofovir
- Specimen Handling
- Sensitivity and Specificity
- Organophosphonates
- Humans
- HIV Infections
- Anti-HIV Agents
Citation
APA
Chicago
ICMJE
MLA
NLM
Hotta, M. T., Broderick, E., & Wyatt, C. M. (2013). Urine processing impacts uric acid level in HIV-infected adults: implications for diagnosing tenofovir-associated proximal tubulopathy. AIDS, 27(11), 1827–1829. https://doi.org/10.1097/QAD.0b013e32836146f6
Hotta, Mathew T., Erin Broderick, and Christina M. Wyatt. “Urine processing impacts uric acid level in HIV-infected adults: implications for diagnosing tenofovir-associated proximal tubulopathy.” AIDS 27, no. 11 (July 17, 2013): 1827–29. https://doi.org/10.1097/QAD.0b013e32836146f6.
Hotta MT, Broderick E, Wyatt CM. Urine processing impacts uric acid level in HIV-infected adults: implications for diagnosing tenofovir-associated proximal tubulopathy. AIDS. 2013 Jul 17;27(11):1827–9.
Hotta, Mathew T., et al. “Urine processing impacts uric acid level in HIV-infected adults: implications for diagnosing tenofovir-associated proximal tubulopathy.” AIDS, vol. 27, no. 11, July 2013, pp. 1827–29. Pubmed, doi:10.1097/QAD.0b013e32836146f6.
Hotta MT, Broderick E, Wyatt CM. Urine processing impacts uric acid level in HIV-infected adults: implications for diagnosing tenofovir-associated proximal tubulopathy. AIDS. 2013 Jul 17;27(11):1827–1829.
Published In
AIDS
DOI
EISSN
1473-5571
Publication Date
July 17, 2013
Volume
27
Issue
11
Start / End Page
1827 / 1829
Location
England
Related Subject Headings
- Virology
- Uric Acid
- Time Factors
- Tenofovir
- Specimen Handling
- Sensitivity and Specificity
- Organophosphonates
- Humans
- HIV Infections
- Anti-HIV Agents