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Factors associated with decreased kidney function in HIV-infected adults enrolled in the MTCT-Plus Initiative in sub-Saharan Africa.

Publication ,  Journal Article
Jao, J; Lo, W; Toro, PL; Wyatt, C; Palmer, D; Abrams, EJ; Carter, RJ; MTCT-Plus Initiative,
Published in: J Acquir Immune Defic Syndr
May 1, 2011

BACKGROUND: Pre-existing kidney disease in HIV-infected patients may necessitate dose modification of antiretroviral therapy (ART). Despite increasing ART availability, there are few prevalence studies of chronic kidney disease in HIV-infected individuals across multiple African countries. METHODS: Routine laboratory data obtained before ART initiation were used to evaluate prevalence and predictors of decreased creatinine clearance (CrCl) in participants of the MTCT-Plus Initiative from 7 sub-Saharan countries. Cockcroft-Gault equation was used to estimate CrCl and logistic regression modeling to identify factors associated with CrCl <50 mL/min. RESULTS: Of 2495 individuals evaluated, median age was 30 years (interquartile range: 27-35); 70% were women. Median CD4+ cell count was 295 (interquartile range: 173-450); 78% were World Health Organization stage 1/2. Median CrCl was 95 mL/min. Overall, 3.4% [95% confidence interval (CI): 2.7 to 4.1] of patients had a CrCl <50 mL/min. Age >30 years (odds ratio = 2.06; 95% CI: 1.23 to 3.45) and CD4+ count <50 cells per cubic millimeter (odds ratio = 5.4 for CD4+ <50, 95% CI: 2.5 to 11.9) were associated with CrCl <50 mL/min. CONCLUSIONS: The prevalence of clinically significant kidney disease was low in this relatively healthy population of HIV-infected adults, and few participants would have required ART dose reductions. These findings support recent World Health Organization guidelines to initiate ART without routine laboratory screening. Our findings suggest that available laboratory resources could be targeted to older persons and those with very low CD4+ cell count.

Duke Scholars

Published In

J Acquir Immune Defic Syndr

DOI

EISSN

1944-7884

Publication Date

May 1, 2011

Volume

57

Issue

1

Start / End Page

40 / 45

Location

United States

Related Subject Headings

  • Virology
  • Risk Factors
  • Prevalence
  • Male
  • Logistic Models
  • Kidney Diseases
  • Humans
  • HIV Infections
  • HIV
  • Female
 

Citation

APA
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MLA
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Jao, J., Lo, W., Toro, P. L., Wyatt, C., Palmer, D., Abrams, E. J., … MTCT-Plus Initiative, . (2011). Factors associated with decreased kidney function in HIV-infected adults enrolled in the MTCT-Plus Initiative in sub-Saharan Africa. J Acquir Immune Defic Syndr, 57(1), 40–45. https://doi.org/10.1097/QAI.0b013e31821008eb
Jao, Jennifer, Wilson Lo, Patricia L. Toro, Christina Wyatt, Dennis Palmer, Elaine J. Abrams, Rosalind J. Carter, and Rosalind J. MTCT-Plus Initiative. “Factors associated with decreased kidney function in HIV-infected adults enrolled in the MTCT-Plus Initiative in sub-Saharan Africa.J Acquir Immune Defic Syndr 57, no. 1 (May 1, 2011): 40–45. https://doi.org/10.1097/QAI.0b013e31821008eb.
Jao J, Lo W, Toro PL, Wyatt C, Palmer D, Abrams EJ, et al. Factors associated with decreased kidney function in HIV-infected adults enrolled in the MTCT-Plus Initiative in sub-Saharan Africa. J Acquir Immune Defic Syndr. 2011 May 1;57(1):40–5.
Jao, Jennifer, et al. “Factors associated with decreased kidney function in HIV-infected adults enrolled in the MTCT-Plus Initiative in sub-Saharan Africa.J Acquir Immune Defic Syndr, vol. 57, no. 1, May 2011, pp. 40–45. Pubmed, doi:10.1097/QAI.0b013e31821008eb.
Jao J, Lo W, Toro PL, Wyatt C, Palmer D, Abrams EJ, Carter RJ, MTCT-Plus Initiative. Factors associated with decreased kidney function in HIV-infected adults enrolled in the MTCT-Plus Initiative in sub-Saharan Africa. J Acquir Immune Defic Syndr. 2011 May 1;57(1):40–45.

Published In

J Acquir Immune Defic Syndr

DOI

EISSN

1944-7884

Publication Date

May 1, 2011

Volume

57

Issue

1

Start / End Page

40 / 45

Location

United States

Related Subject Headings

  • Virology
  • Risk Factors
  • Prevalence
  • Male
  • Logistic Models
  • Kidney Diseases
  • Humans
  • HIV Infections
  • HIV
  • Female