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Peripheral blood metabolite profiles associated with new onset atrial fibrillation.

Publication ,  Journal Article
Harskamp, RE; Granger, TM; Clare, RM; White, KR; Lopes, RD; Pieper, KS; Granger, CB; Newgard, CB; Shah, SH; Newby, LK
Published in: Am Heart J
May 2019

BACKGROUND: Peripheral blood metabolite profiles have yielded mechanistic insights into various cardiovascular disease states. We hypothesized that peripheral blood metabolite profiles would be associated with new onset atrial fibrillation (AF). METHODS AND RESULTS: The study population comprised 1892 patients without AF at baseline, who, as part the MURDOCK Cardiovascular Disease Study molecular profiling cohort (n = 2023), had previously had determination of levels of 69 metabolites from frozen, fasting plasma specimens obtained during coronary angiography. We used Cox proportional hazards models to examine the association of 13 uncorrelated metabolite factors created from these data using principal components analysis (PCA) with new occurrences of AF during a median follow up of 2.8 (0.1-4.9) years. A total of 233 patients developed new AF (12.3%) during follow up. Patients with new onset AF were older (median 67 vs. 60 years); more often white (82 vs. 71%) and male (68 vs. 60%), and had more comorbidities than those who did not develop AF. After adjustment, PCA factor 1 (medium chain acylcarnitines; hazard ratio [HR]: 1.11 [1.01-1.22]), factor 2 (short chain dicarboxylacylcarnitines; HR: 1.21 [1.09-1.34]) and factor 5 (long chain acylcarnitines; HR: 1.19 [1.06-1.34]) were associated with new onset AF. CONCLUSION: Metabolite profiles were associated with new onset AF among patients referred for coronary angiography. Validation of these observations in broader patient populations may provide better mechanistic insight into the development of AF, and may provide new opportunities for prevention and treatment.

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Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

May 2019

Volume

211

Start / End Page

54 / 59

Location

United States

Related Subject Headings

  • Risk Factors
  • Proportional Hazards Models
  • Principal Component Analysis
  • Mitochondria, Heart
  • Middle Aged
  • Male
  • Humans
  • Follow-Up Studies
  • Female
  • Fatty Acids
 

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APA
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MLA
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Harskamp, R. E., Granger, T. M., Clare, R. M., White, K. R., Lopes, R. D., Pieper, K. S., … Newby, L. K. (2019). Peripheral blood metabolite profiles associated with new onset atrial fibrillation. Am Heart J, 211, 54–59. https://doi.org/10.1016/j.ahj.2019.01.010
Harskamp, Ralf E., Thomas M. Granger, Robert M. Clare, Kyle R. White, Renato D. Lopes, Karen S. Pieper, Christopher B. Granger, Christopher B. Newgard, Svati H. Shah, and L Kristin Newby. “Peripheral blood metabolite profiles associated with new onset atrial fibrillation.Am Heart J 211 (May 2019): 54–59. https://doi.org/10.1016/j.ahj.2019.01.010.
Harskamp RE, Granger TM, Clare RM, White KR, Lopes RD, Pieper KS, et al. Peripheral blood metabolite profiles associated with new onset atrial fibrillation. Am Heart J. 2019 May;211:54–9.
Harskamp, Ralf E., et al. “Peripheral blood metabolite profiles associated with new onset atrial fibrillation.Am Heart J, vol. 211, May 2019, pp. 54–59. Pubmed, doi:10.1016/j.ahj.2019.01.010.
Harskamp RE, Granger TM, Clare RM, White KR, Lopes RD, Pieper KS, Granger CB, Newgard CB, Shah SH, Newby LK. Peripheral blood metabolite profiles associated with new onset atrial fibrillation. Am Heart J. 2019 May;211:54–59.
Journal cover image

Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

May 2019

Volume

211

Start / End Page

54 / 59

Location

United States

Related Subject Headings

  • Risk Factors
  • Proportional Hazards Models
  • Principal Component Analysis
  • Mitochondria, Heart
  • Middle Aged
  • Male
  • Humans
  • Follow-Up Studies
  • Female
  • Fatty Acids