Skip to main content
Journal cover image

Glycated Hemoglobin and All-Cause and Cause-Specific Mortality Among Adults With and Without Diabetes.

Publication ,  Journal Article
Li, F-R; Zhang, X-R; Zhong, W-F; Li, Z-H; Gao, X; Kraus, VB; Lv, Y-B; Zou, M-C; Chen, G-C; Chen, P-L; Zhang, M-Y; Kur, AKA; Shi, X-M; Wu, X-B; Mao, C
Published in: J Clin Endocrinol Metab
August 1, 2019

CONTEXT: The patterns of associations between glycated Hb (HbA1c) and mortality are still unclear. OBJECTIVE: To explore the extent to which ranges of HbA1c levels are associated with the risk of mortality among participants with and without diabetes. DESIGN, SETTING, AND PATIENTS: This was a nationwide, community-based prospective cohort study. Included were 15,869 participants (median age 64 years) of the Health and Retirement Study, with available HbA1c data and without a history of cancer. Cox proportional hazards regression models were used to estimate hazard ratios with 95% CIs for mortality. RESULTS: A total of 2133 participants died during a median follow-up of 5.8 years. In participants with diabetes, those with an HbA1c level of 6.5% were at the lowest risk of all-cause mortality. When HbA1c level was <5.6% or >7.4%, the increased all-cause mortality risk became statistically significant as compared with an HbA1c level of 6.5%. As for participants without diabetes, those with an HbA1c level of 5.4% were at the lowest risk of all-cause mortality. When the HbA1c level was <5.0%, the increased all-cause mortality risk became statistically significant as compared with an HbA1c level of 5.4%. However, we did not observe a statistically significant elevated risk of all-cause mortality above an HbA1c level of 5.4%. CONCLUSIONS: A U-shaped and reverse J-shaped association for all-cause mortality was found among participants with and without diabetes. The corresponding optimal ranges for overall survival are predicted to be 5.6% and 7.4% and 5.0% and 6.5%, respectively.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Clin Endocrinol Metab

DOI

EISSN

1945-7197

Publication Date

August 1, 2019

Volume

104

Issue

8

Start / End Page

3345 / 3354

Location

United States

Related Subject Headings

  • Survival Rate
  • Prospective Studies
  • Proportional Hazards Models
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Humans
  • Glycated Hemoglobin
  • Female
  • Endocrinology & Metabolism
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Li, F.-R., Zhang, X.-R., Zhong, W.-F., Li, Z.-H., Gao, X., Kraus, V. B., … Mao, C. (2019). Glycated Hemoglobin and All-Cause and Cause-Specific Mortality Among Adults With and Without Diabetes. J Clin Endocrinol Metab, 104(8), 3345–3354. https://doi.org/10.1210/jc.2018-02536
Li, Fu-Rong, Xi-Ru Zhang, Wen-Fang Zhong, Zhi-Hao Li, Xiang Gao, Virginia Byers Kraus, Yue-Bin Lv, et al. “Glycated Hemoglobin and All-Cause and Cause-Specific Mortality Among Adults With and Without Diabetes.J Clin Endocrinol Metab 104, no. 8 (August 1, 2019): 3345–54. https://doi.org/10.1210/jc.2018-02536.
Li F-R, Zhang X-R, Zhong W-F, Li Z-H, Gao X, Kraus VB, et al. Glycated Hemoglobin and All-Cause and Cause-Specific Mortality Among Adults With and Without Diabetes. J Clin Endocrinol Metab. 2019 Aug 1;104(8):3345–54.
Li, Fu-Rong, et al. “Glycated Hemoglobin and All-Cause and Cause-Specific Mortality Among Adults With and Without Diabetes.J Clin Endocrinol Metab, vol. 104, no. 8, Aug. 2019, pp. 3345–54. Pubmed, doi:10.1210/jc.2018-02536.
Li F-R, Zhang X-R, Zhong W-F, Li Z-H, Gao X, Kraus VB, Lv Y-B, Zou M-C, Chen G-C, Chen P-L, Zhang M-Y, Kur AKA, Shi X-M, Wu X-B, Mao C. Glycated Hemoglobin and All-Cause and Cause-Specific Mortality Among Adults With and Without Diabetes. J Clin Endocrinol Metab. 2019 Aug 1;104(8):3345–3354.
Journal cover image

Published In

J Clin Endocrinol Metab

DOI

EISSN

1945-7197

Publication Date

August 1, 2019

Volume

104

Issue

8

Start / End Page

3345 / 3354

Location

United States

Related Subject Headings

  • Survival Rate
  • Prospective Studies
  • Proportional Hazards Models
  • Middle Aged
  • Male
  • Longitudinal Studies
  • Humans
  • Glycated Hemoglobin
  • Female
  • Endocrinology & Metabolism