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Histone demethylases in neuronal differentiation, plasticity, and disease.

Publication ,  Journal Article
Swahari, V; West, AE
Published in: Curr Opin Neurobiol
December 2019

For more than 40 years after its discovery, histone methylation was thought to be largely irreversible. However, the first histone demethylase (HDM) was identified in 2004, challenging this notion. Since that time, more than 20 HDMs have been identified and characterized, and many have been shown to have critical roles in organismal development, cell fate, and disease. Here, we highlight some of the recent advances in our understanding of the function of HDMs in the context of neuronal development, plasticity, and disease. We focus, in particular, on molecular genetic studies of LSD1, Kdm6b, and Kdm5c that have elucidated both enzymatic and non-enzymatic gene regulatory functions of these HDMs in neurons.

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Published In

Curr Opin Neurobiol

DOI

EISSN

1873-6882

Publication Date

December 2019

Volume

59

Start / End Page

9 / 15

Location

England

Related Subject Headings

  • Neurons
  • Neurogenesis
  • Histones
  • Histone Demethylases
  • Cell Polarity
  • Cell Differentiation
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
  • 1109 Neurosciences
 

Citation

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Swahari, V., & West, A. E. (2019). Histone demethylases in neuronal differentiation, plasticity, and disease. Curr Opin Neurobiol, 59, 9–15. https://doi.org/10.1016/j.conb.2019.02.009
Swahari, Vijay, and Anne E. West. “Histone demethylases in neuronal differentiation, plasticity, and disease.Curr Opin Neurobiol 59 (December 2019): 9–15. https://doi.org/10.1016/j.conb.2019.02.009.
Swahari V, West AE. Histone demethylases in neuronal differentiation, plasticity, and disease. Curr Opin Neurobiol. 2019 Dec;59:9–15.
Swahari, Vijay, and Anne E. West. “Histone demethylases in neuronal differentiation, plasticity, and disease.Curr Opin Neurobiol, vol. 59, Dec. 2019, pp. 9–15. Pubmed, doi:10.1016/j.conb.2019.02.009.
Swahari V, West AE. Histone demethylases in neuronal differentiation, plasticity, and disease. Curr Opin Neurobiol. 2019 Dec;59:9–15.
Journal cover image

Published In

Curr Opin Neurobiol

DOI

EISSN

1873-6882

Publication Date

December 2019

Volume

59

Start / End Page

9 / 15

Location

England

Related Subject Headings

  • Neurons
  • Neurogenesis
  • Histones
  • Histone Demethylases
  • Cell Polarity
  • Cell Differentiation
  • 3209 Neurosciences
  • 1702 Cognitive Sciences
  • 1109 Neurosciences