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Oral tolerance and pyruvate dehydrogenase in patients with primary biliary cirrhosis.

Publication ,  Journal Article
Suzuki, A; Van de Water, J; Gershwin, ME; Jorgensen, R; Angulo, P; Lindor, K
Published in: Dev Immunol
June 2002

Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease characterized by the immunological destruction of intralobular bile ducts and serum anti-mitochondrial antibodies (AMA). Based upon previous work of oral tolerance and autoimmunity, we hypothesized that feeding the mitochondrial autoantigens of PBC would alter the clinical course and the level of antimitochondrial antibodies. The bovine pyruvate dehydrogenase complex (PDC) was purified and 5 mg fed in gelatin capsules to 6 patients with early stage PBC for 6 months. Antimitochondrial antibodies and liver biochemistries were measured at every 3 months for 12 months. The clinical trial was completed for all patients except for 1 who showed deterioration of pre-existing skin rash during treatment, which disappeared within 2 weeks after treatment was discontinued. However, after 1 year, neither the titers of AMAs nor liver biochemistries were significantly changed by this treatment. This is the first trial to test the efficacy of oral tolerance induction in PBC. However, the data, which limited in scope, did not demonstrate efficacy and further highlights the difficulties in showing continuing evidence of tolerance induction in autoimmunity.

Duke Scholars

Published In

Dev Immunol

DOI

ISSN

1044-6672

Publication Date

June 2002

Volume

9

Issue

2

Start / End Page

55 / 61

Location

England

Related Subject Headings

  • Pyruvate Dehydrogenase Complex
  • Mitochondria
  • Middle Aged
  • Liver Cirrhosis, Biliary
  • Immunosuppression Therapy
  • Immunology
  • Immune Tolerance
  • Humans
  • Female
  • Cattle
 

Citation

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Suzuki, A., Van de Water, J., Gershwin, M. E., Jorgensen, R., Angulo, P., & Lindor, K. (2002). Oral tolerance and pyruvate dehydrogenase in patients with primary biliary cirrhosis. Dev Immunol, 9(2), 55–61. https://doi.org/10.1080/1044667021000098561
Suzuki, Ayako, Judy Van de Water, M Eric Gershwin, Roberta Jorgensen, Paul Angulo, and Keith Lindor. “Oral tolerance and pyruvate dehydrogenase in patients with primary biliary cirrhosis.Dev Immunol 9, no. 2 (June 2002): 55–61. https://doi.org/10.1080/1044667021000098561.
Suzuki A, Van de Water J, Gershwin ME, Jorgensen R, Angulo P, Lindor K. Oral tolerance and pyruvate dehydrogenase in patients with primary biliary cirrhosis. Dev Immunol. 2002 Jun;9(2):55–61.
Suzuki, Ayako, et al. “Oral tolerance and pyruvate dehydrogenase in patients with primary biliary cirrhosis.Dev Immunol, vol. 9, no. 2, June 2002, pp. 55–61. Pubmed, doi:10.1080/1044667021000098561.
Suzuki A, Van de Water J, Gershwin ME, Jorgensen R, Angulo P, Lindor K. Oral tolerance and pyruvate dehydrogenase in patients with primary biliary cirrhosis. Dev Immunol. 2002 Jun;9(2):55–61.

Published In

Dev Immunol

DOI

ISSN

1044-6672

Publication Date

June 2002

Volume

9

Issue

2

Start / End Page

55 / 61

Location

England

Related Subject Headings

  • Pyruvate Dehydrogenase Complex
  • Mitochondria
  • Middle Aged
  • Liver Cirrhosis, Biliary
  • Immunosuppression Therapy
  • Immunology
  • Immune Tolerance
  • Humans
  • Female
  • Cattle