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General anesthetic exposure in adolescent rats causes persistent maladaptations in cognitive and affective behaviors and neuroplasticity.

Publication ,  Journal Article
Landin, JD; Palac, M; Carter, JM; Dzumaga, Y; Santerre-Anderson, JL; Fernandez, GM; Savage, LM; Varlinskaya, EI; Spear, LP; Moore, SD ...
Published in: Neuropharmacology
May 15, 2019

Accumulating evidence indicates that exposure to general anesthetics during infancy and childhood can cause persistent cognitive impairment, alterations in synaptic plasticity, and, to a lesser extent, increased incidence of behavioral disorders. Unfortunately, the developmental parameters of susceptibility to general anesthetics are not well understood. Adolescence is a critical developmental period wherein multiple late developing brain regions may also be vulnerable to enduring general anesthetic effects. Given the breadth of the adolescent age span, this group potentially represents millions more individuals than those exposed during early childhood. In this study, isoflurane exposure within a well-characterized adolescent period in Sprague-Dawley rats elicited immediate and persistent anxiety- and impulsive-like responding, as well as delayed cognitive impairment into adulthood. These behavioral abnormalities were paralleled by atypical dendritic spine morphology in the prefrontal cortex (PFC) and hippocampus (HPC), suggesting delayed anatomical maturation, and shifts in inhibitory function that suggest hypermaturation of extrasynaptic GABAA receptor inhibition. Preventing this hypermaturation of extrasynaptic GABAA receptor-mediated function in the PFC selectively reversed enhanced impulsivity resulting from adolescent isoflurane exposure. Taken together, these data demonstrate that the developmental window for susceptibility to enduring untoward effects of general anesthetics may be much longer than previously appreciated, and those effects may include affective behaviors in addition to cognition.

Duke Scholars

Published In

Neuropharmacology

DOI

EISSN

1873-7064

Publication Date

May 15, 2019

Volume

150

Start / End Page

153 / 163

Location

England

Related Subject Headings

  • Rats, Sprague-Dawley
  • Rats
  • Pyramidal Cells
  • Prefrontal Cortex
  • Neuronal Plasticity
  • Neurology & Neurosurgery
  • Male
  • Isoflurane
  • Impulsive Behavior
  • Exploratory Behavior
 

Citation

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MLA
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Landin, J. D., Palac, M., Carter, J. M., Dzumaga, Y., Santerre-Anderson, J. L., Fernandez, G. M., … Werner, D. F. (2019). General anesthetic exposure in adolescent rats causes persistent maladaptations in cognitive and affective behaviors and neuroplasticity. Neuropharmacology, 150, 153–163. https://doi.org/10.1016/j.neuropharm.2019.03.022
Landin, Justine D., Magdalena Palac, Jenna M. Carter, Yvette Dzumaga, Jessica L. Santerre-Anderson, Gina M. Fernandez, Lisa M. Savage, et al. “General anesthetic exposure in adolescent rats causes persistent maladaptations in cognitive and affective behaviors and neuroplasticity.Neuropharmacology 150 (May 15, 2019): 153–63. https://doi.org/10.1016/j.neuropharm.2019.03.022.
Landin JD, Palac M, Carter JM, Dzumaga Y, Santerre-Anderson JL, Fernandez GM, et al. General anesthetic exposure in adolescent rats causes persistent maladaptations in cognitive and affective behaviors and neuroplasticity. Neuropharmacology. 2019 May 15;150:153–63.
Landin, Justine D., et al. “General anesthetic exposure in adolescent rats causes persistent maladaptations in cognitive and affective behaviors and neuroplasticity.Neuropharmacology, vol. 150, May 2019, pp. 153–63. Pubmed, doi:10.1016/j.neuropharm.2019.03.022.
Landin JD, Palac M, Carter JM, Dzumaga Y, Santerre-Anderson JL, Fernandez GM, Savage LM, Varlinskaya EI, Spear LP, Moore SD, Swartzwelder HS, Fleming RL, Werner DF. General anesthetic exposure in adolescent rats causes persistent maladaptations in cognitive and affective behaviors and neuroplasticity. Neuropharmacology. 2019 May 15;150:153–163.
Journal cover image

Published In

Neuropharmacology

DOI

EISSN

1873-7064

Publication Date

May 15, 2019

Volume

150

Start / End Page

153 / 163

Location

England

Related Subject Headings

  • Rats, Sprague-Dawley
  • Rats
  • Pyramidal Cells
  • Prefrontal Cortex
  • Neuronal Plasticity
  • Neurology & Neurosurgery
  • Male
  • Isoflurane
  • Impulsive Behavior
  • Exploratory Behavior