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Biomarkers Implicated in Lower Urinary Tract Symptoms: Systematic Review and Pathway Analyses.

Publication ,  Journal Article
Siddiqui, NY; Helfand, BT; Andreev, VP; Kowalski, JT; Bradley, MS; Lai, HH; Berger, MB; Mueller, MG; Bickhaus, JA; Packiam, VT; Fenner, D ...
Published in: J Urol
November 2019

PURPOSE: Lower urinary tract symptoms are prevalent and burdensome, yet methods to enhance diagnosis and appropriately guide therapies are lacking. We systematically reviewed the literature for human studies of biomarkers associated with lower urinary tract symptoms. MATERIALS AND METHODS: PubMed®, EMBASE® and Web of Science® were searched from inception to February 13, 2018. Articles were included if they were in English, performed in benign urological populations without neurological disorders or interstitial cystitis/bladder pain syndrome, and assessed a biomarker's association with or ability to predict specific lower urinary tract symptoms or urological conditions. Bioinformatic pathway analyses were conducted to determine whether individual biomarkers associated with symptoms are present in unifying pathways. RESULTS: Of 6,150 citations identified 125 met the inclusion criteria. Most studies (93.6%) assessed biomarkers at 1 time point and were cross-sectional in nature. Few studies adjusted for potentially confounding clinical variables or assessed biomarkers in an individual over time. No individual biomarkers are currently validated as diagnostic tools for lower urinary tract symptoms. Compared to controls, pathway analyses identified multiple immune response pathways that were enriched in overactive bladder syndrome and cell migration/cytoskeleton remodeling pathways that were enriched in female stress incontinence. CONCLUSIONS: Major deficiencies in the existing biomarker literature include poor reproducibility of laboratory data, unclear classification of patients with lower urinary tract symptoms and lack of adjustment for clinical covariates. Despite these limitations we identified multiple putative pathways in which panels of biological markers need further research.

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Published In

J Urol

DOI

EISSN

1527-3792

Publication Date

November 2019

Volume

202

Issue

5

Start / End Page

880 / 889

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Urination
  • Lower Urinary Tract Symptoms
  • Humans
  • Biomarkers
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

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Siddiqui, N. Y., Helfand, B. T., Andreev, V. P., Kowalski, J. T., Bradley, M. S., Lai, H. H., … Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN), . (2019). Biomarkers Implicated in Lower Urinary Tract Symptoms: Systematic Review and Pathway Analyses. J Urol, 202(5), 880–889. https://doi.org/10.1097/JU.0000000000000257
Siddiqui, Nazema Y., Brian T. Helfand, Victor P. Andreev, Joseph T. Kowalski, Megan S. Bradley, H Henry Lai, Mitchell B. Berger, et al. “Biomarkers Implicated in Lower Urinary Tract Symptoms: Systematic Review and Pathway Analyses.J Urol 202, no. 5 (November 2019): 880–89. https://doi.org/10.1097/JU.0000000000000257.
Siddiqui NY, Helfand BT, Andreev VP, Kowalski JT, Bradley MS, Lai HH, et al. Biomarkers Implicated in Lower Urinary Tract Symptoms: Systematic Review and Pathway Analyses. J Urol. 2019 Nov;202(5):880–9.
Siddiqui, Nazema Y., et al. “Biomarkers Implicated in Lower Urinary Tract Symptoms: Systematic Review and Pathway Analyses.J Urol, vol. 202, no. 5, Nov. 2019, pp. 880–89. Pubmed, doi:10.1097/JU.0000000000000257.
Siddiqui NY, Helfand BT, Andreev VP, Kowalski JT, Bradley MS, Lai HH, Berger MB, Mueller MG, Bickhaus JA, Packiam VT, Fenner D, Gillispie BW, Kirkali Z, Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN). Biomarkers Implicated in Lower Urinary Tract Symptoms: Systematic Review and Pathway Analyses. J Urol. 2019 Nov;202(5):880–889.
Journal cover image

Published In

J Urol

DOI

EISSN

1527-3792

Publication Date

November 2019

Volume

202

Issue

5

Start / End Page

880 / 889

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Urination
  • Lower Urinary Tract Symptoms
  • Humans
  • Biomarkers
  • 3202 Clinical sciences
  • 1103 Clinical Sciences