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Effects of air pollution on mitochondrial function, mitochondrial DNA methylation, and mitochondrial peptide expression.

Publication ,  Journal Article
Breton, CV; Song, AY; Xiao, J; Kim, S-J; Mehta, HH; Wan, J; Yen, K; Sioutas, C; Lurmann, F; Xue, S; Morgan, TE; Zhang, J; Cohen, P
Published in: Mitochondrion
May 2019

Mitochondrial DNA is sensitive to damage by exogenous reactive oxygen sources, including traffic-related air pollution (TRAP). Given the important role for mitochondria in human disease, we hypothesized that prenatal air pollution exposure may be associated with mitochondrial dysfunction and that mitochondrial-derived peptides (MDPs) might protect against these effects. In in vitro studies, 24-hour exposure to nanoparticulate matter (nPM) increased oxidation of mtDNA, decreased mitochondrial consumption rate (OCR), and decreased mtDNAcn in SH-SY5Y cells. Addition of MDPs rescued these effects to varying degrees. Liver tissue taken from C57Bl/6 males exposed for 10 weeks to nPM had lower OCR, lower mtDNAcn and higher MDP levels, similar to in vitro studies. In newborn cord blood, MDP levels were positively associated with prenatal TRAP exposures. Moreover, DNA methylation of two distinct regions of the D-Loop in the mitochondria genome was associated with levels of several MDPs. Our in vitro and in vivo data indicate that TRAP can directly affect mitochondrial respiratory function and mtDNAcn. Treatment of cells with MDPs can counteract TRAP induced-effects. Lastly, we present evidence that suggests MDPs may be regulated in part by mitochondrial DNA methylation in humans.

Duke Scholars

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Published In

Mitochondrion

DOI

EISSN

1872-8278

ISSN

1567-7249

Publication Date

May 2019

Volume

46

Start / End Page

22 / 29

Related Subject Headings

  • Young Adult
  • Pregnancy
  • Models, Animal
  • Mitochondrial Proteins
  • Mitochondria
  • Mice, Inbred C57BL
  • Male
  • Infant, Newborn
  • Infant
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Breton, C. V., Song, A. Y., Xiao, J., Kim, S.-J., Mehta, H. H., Wan, J., … Cohen, P. (2019). Effects of air pollution on mitochondrial function, mitochondrial DNA methylation, and mitochondrial peptide expression. Mitochondrion, 46, 22–29. https://doi.org/10.1016/j.mito.2019.04.001
Breton, Carrie V., Ashley Y. Song, Jialin Xiao, Su-Jeong Kim, Hemal H. Mehta, Junxiang Wan, Kelvin Yen, et al. “Effects of air pollution on mitochondrial function, mitochondrial DNA methylation, and mitochondrial peptide expression.Mitochondrion 46 (May 2019): 22–29. https://doi.org/10.1016/j.mito.2019.04.001.
Breton CV, Song AY, Xiao J, Kim S-J, Mehta HH, Wan J, et al. Effects of air pollution on mitochondrial function, mitochondrial DNA methylation, and mitochondrial peptide expression. Mitochondrion. 2019 May;46:22–9.
Breton, Carrie V., et al. “Effects of air pollution on mitochondrial function, mitochondrial DNA methylation, and mitochondrial peptide expression.Mitochondrion, vol. 46, May 2019, pp. 22–29. Epmc, doi:10.1016/j.mito.2019.04.001.
Breton CV, Song AY, Xiao J, Kim S-J, Mehta HH, Wan J, Yen K, Sioutas C, Lurmann F, Xue S, Morgan TE, Zhang J, Cohen P. Effects of air pollution on mitochondrial function, mitochondrial DNA methylation, and mitochondrial peptide expression. Mitochondrion. 2019 May;46:22–29.
Journal cover image

Published In

Mitochondrion

DOI

EISSN

1872-8278

ISSN

1567-7249

Publication Date

May 2019

Volume

46

Start / End Page

22 / 29

Related Subject Headings

  • Young Adult
  • Pregnancy
  • Models, Animal
  • Mitochondrial Proteins
  • Mitochondria
  • Mice, Inbred C57BL
  • Male
  • Infant, Newborn
  • Infant
  • Humans