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Serum levels of fibroblast growth factor 23 are elevated in patients with active Lupus nephritis.

Publication ,  Journal Article
Resende, AL; Elias, RM; Wolf, M; Dos Reis, LM; Graciolli, FG; Santos, GD; Dias, CB; Jorgetti, V; Woronik, V; Moysés, RMA
Published in: Cytokine
March 2017

BACKGROUND: Fibroblast growth factor 23 (FGF23), a phosphate-regulating hormone is an established cardiovascular risk factor. Recently, FGF23 has been related to inflammation. Lupus is an inflammatory disease, and whether FGF23 is associated with Lupus nephritis (LN) activity is unknown. MATERIALS AND METHODS: We studied 15 pre-menopausal patients with recent LN diagnose (⩽2months) and compared them to 1:1 age-matched healthy control group. We measured serum levels of intact FGF23, interleukin-6 (IL-6), tumor necrosis factor α (TNFα), and urinary levels of monocyte chemotactic protein (MCP1). RESULTS: LN patients (29.5±10years) presented proteinuria of 4.7±2.9g/day, and estimated glomerular filtration rate of 37 (31-87)ml/min/1.73m2. They demonstrated higher FGF23 levels when compared to healthy controls [106.7 (80.3-179) vs. 33.6 (25.8-60.9) pg/ml, p<0.001]. FGF23 levels correlated with urinary MCP1 (r=0.62, p<0.001), serum TNFα (r=0.58, p<0.001) and serum IL-6 (r=0.46, p=0.01). Only the correlation between FGF23 and MCP1 remained significant after adjustments for 25(OH) vitamin D and renal function. CONCLUSION: Newly diagnosed LN patients demonstrated elevated FGF23 levels that were positively correlated to urinary MCP1, independently of vitamin D levels and kidney function. If FGF23 may predict clinical outcomes in LN warrants further evaluation.

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Published In

Cytokine

DOI

EISSN

1096-0023

Publication Date

March 2017

Volume

91

Start / End Page

124 / 127

Location

England

Related Subject Headings

  • Vitamin D
  • Premenopause
  • Lupus Nephritis
  • Immunology
  • Humans
  • Fibroblast Growth Factors
  • Fibroblast Growth Factor-23
  • Female
  • Chemokine CCL2
  • Adult
 

Citation

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Resende, A. L., Elias, R. M., Wolf, M., Dos Reis, L. M., Graciolli, F. G., Santos, G. D., … Moysés, R. M. A. (2017). Serum levels of fibroblast growth factor 23 are elevated in patients with active Lupus nephritis. Cytokine, 91, 124–127. https://doi.org/10.1016/j.cyto.2016.12.022
Resende, Aline L., Rosilene M. Elias, Myles Wolf, Luciene M. Dos Reis, Fabiana G. Graciolli, Geuza D. Santos, Cristiane B. Dias, Vanda Jorgetti, Viktoria Woronik, and Rosa M. A. Moysés. “Serum levels of fibroblast growth factor 23 are elevated in patients with active Lupus nephritis.Cytokine 91 (March 2017): 124–27. https://doi.org/10.1016/j.cyto.2016.12.022.
Resende AL, Elias RM, Wolf M, Dos Reis LM, Graciolli FG, Santos GD, et al. Serum levels of fibroblast growth factor 23 are elevated in patients with active Lupus nephritis. Cytokine. 2017 Mar;91:124–7.
Resende, Aline L., et al. “Serum levels of fibroblast growth factor 23 are elevated in patients with active Lupus nephritis.Cytokine, vol. 91, Mar. 2017, pp. 124–27. Pubmed, doi:10.1016/j.cyto.2016.12.022.
Resende AL, Elias RM, Wolf M, Dos Reis LM, Graciolli FG, Santos GD, Dias CB, Jorgetti V, Woronik V, Moysés RMA. Serum levels of fibroblast growth factor 23 are elevated in patients with active Lupus nephritis. Cytokine. 2017 Mar;91:124–127.

Published In

Cytokine

DOI

EISSN

1096-0023

Publication Date

March 2017

Volume

91

Start / End Page

124 / 127

Location

England

Related Subject Headings

  • Vitamin D
  • Premenopause
  • Lupus Nephritis
  • Immunology
  • Humans
  • Fibroblast Growth Factors
  • Fibroblast Growth Factor-23
  • Female
  • Chemokine CCL2
  • Adult