Skip to main content

High-sensitivity troponin T and N-terminal pro-B-type natriuretic peptide (NT-proBNP) and risk of incident heart failure in patients with CKD: the Chronic Renal Insufficiency Cohort (CRIC) Study.

Publication ,  Journal Article
Bansal, N; Hyre Anderson, A; Yang, W; Christenson, RH; deFilippi, CR; Deo, R; Dries, DL; Go, AS; He, J; Kusek, JW; Lash, JP; Raj, D; Rosas, S ...
Published in: J Am Soc Nephrol
April 2015

High-sensitivity troponin T (hsTnT) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) strongly predict heart failure (HF) in the general population. However, the interpretation of levels of these biomarkers as predictors of HF is uncertain among patients with CKD. Here, we investigated whether hsTnT and NT-proBNP are associated with incident HF among patients with CKD. In a prospective cohort analysis, we studied 3483 people with CKD in the Chronic Renal Insufficiency Cohort (CRIC) Study recruited from June of 2003 to August of 2008 who were free of HF at baseline. We used Cox regression to examine the association of baseline levels of hsTnT and NT-proBNP with incident HF after adjustment for demographic factors, traditional cardiovascular risk factors, markers of kidney disease, pertinent medication use, and mineral metabolism markers. At baseline, hsTnT levels ranged from ≤5.0 to 738.7 pg/ml, and NT-proBNP levels ranged from ≤5 to 35,000 pg/ml. Compared with those who had undetectable hsTnT, participants in the highest quartile (>26.5 pg/ml) had a significantly higher rate of HF (hazard ratio, 4.77; 95% confidence interval, 2.49 to 9.14). Similarly, compared with those in the lowest NT-proBNP quintile (<47.6 pg/ml), participants in the highest quintile (>433.0 pg/ml) experienced a substantially higher rate of HF (hazard ratio, 9.57; 95% confidence interval, 4.40 to 20.83) [corrected]. In conclusion, hsTnT and NT-proBNP were strongly associated with incident HF among a diverse cohort of individuals with mild to severe CKD. Elevations in these biomarkers may indicate subclinical changes in volume and myocardial stress that subsequently contribute to clinical HF.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Am Soc Nephrol

DOI

EISSN

1533-3450

Publication Date

April 2015

Volume

26

Issue

4

Start / End Page

946 / 956

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Troponin T
  • Renal Insufficiency, Chronic
  • Peptide Fragments
  • Natriuretic Peptide, Brain
  • Middle Aged
  • Male
  • Humans
  • Heart Failure
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Bansal, N., Hyre Anderson, A., Yang, W., Christenson, R. H., deFilippi, C. R., Deo, R., … Feldman, H. I. (2015). High-sensitivity troponin T and N-terminal pro-B-type natriuretic peptide (NT-proBNP) and risk of incident heart failure in patients with CKD: the Chronic Renal Insufficiency Cohort (CRIC) Study. J Am Soc Nephrol, 26(4), 946–956. https://doi.org/10.1681/ASN.2014010108
Bansal, Nisha, Amanda Hyre Anderson, Wei Yang, Robert H. Christenson, Christopher R. deFilippi, Rajat Deo, Daniel L. Dries, et al. “High-sensitivity troponin T and N-terminal pro-B-type natriuretic peptide (NT-proBNP) and risk of incident heart failure in patients with CKD: the Chronic Renal Insufficiency Cohort (CRIC) Study.J Am Soc Nephrol 26, no. 4 (April 2015): 946–56. https://doi.org/10.1681/ASN.2014010108.
Bansal N, Hyre Anderson A, Yang W, Christenson RH, deFilippi CR, Deo R, Dries DL, Go AS, He J, Kusek JW, Lash JP, Raj D, Rosas S, Wolf M, Zhang X, Shlipak MG, Feldman HI. High-sensitivity troponin T and N-terminal pro-B-type natriuretic peptide (NT-proBNP) and risk of incident heart failure in patients with CKD: the Chronic Renal Insufficiency Cohort (CRIC) Study. J Am Soc Nephrol. 2015 Apr;26(4):946–956.

Published In

J Am Soc Nephrol

DOI

EISSN

1533-3450

Publication Date

April 2015

Volume

26

Issue

4

Start / End Page

946 / 956

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Troponin T
  • Renal Insufficiency, Chronic
  • Peptide Fragments
  • Natriuretic Peptide, Brain
  • Middle Aged
  • Male
  • Humans
  • Heart Failure
  • Female