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Fibroblast growth factor 23 and Inflammation in CKD.

Publication ,  Journal Article
Munoz Mendoza, J; Isakova, T; Ricardo, AC; Xie, H; Navaneethan, SD; Anderson, AH; Bazzano, LA; Xie, D; Kretzler, M; Nessel, L; Hamm, LL ...
Published in: Clin J Am Soc Nephrol
July 2012

BACKGROUND AND OBJECTIVES: Levels of fibroblast growth factor 23 (FGF23) and inflammatory markers are commonly elevated in CKD, and each is associated with adverse clinical outcomes. This study tested the hypothesis that FGF23 is independently associated with inflammation in CKD. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: The association between levels of FGF23 and the inflammatory markers IL-6, C-reactive protein (CRP), TNF-α, and fibrinogen was assessed in a cross-sectional analysis of 3879 participants enrolled in the Chronic Renal Insufficiency Cohort (CRIC) study between June 2003 and September 2008. RESULTS: FGF23 correlated directly with IL-6 (r=0.4), CRP (r=0.2), TNF-α (r=0.4), and fibrinogen (r=0.3; P<0.001 for each). In univariate and multivariable-adjusted linear regression analyses, natural log (ln) transformed FGF23 was significantly associated with lnIL-6, lnCRP, lnTNF-α, and fibrinogen (P<0.001 for each). Each unit higher lnFGF23 was associated with severe inflammation, defined as levels of all inflammatory markers in the highest 25th percentile, in univariate (odds ratio [OR], 2.4 [95% confidence interval (CI), 2.0-2.9]) and multivariable-adjusted (OR, 2.0 [95% CI, 1.6-2.5]) logistic regression analyses. Ascending FGF23 quartiles were independently associated with severe inflammation (OR, 5.6 for the highest versus lowest FGF23 quartile [95% CI, 2.3-13.9]; P for trend < 0.001). CONCLUSIONS: Higher FGF23 levels are independently associated with higher levels of inflammatory markers in patients with CKD and with significantly greater odds of severe inflammation. Future studies should evaluate whether inflammation modifies the association between FGF23 and adverse outcomes in CKD.

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Published In

Clin J Am Soc Nephrol

DOI

EISSN

1555-905X

Publication Date

July 2012

Volume

7

Issue

7

Start / End Page

1155 / 1162

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Renal Insufficiency, Chronic
  • Prospective Studies
  • Middle Aged
  • Male
  • Inflammation
  • Humans
  • Fibroblast Growth Factors
  • Fibroblast Growth Factor-23
  • Female
 

Citation

APA
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Munoz Mendoza, J., Isakova, T., Ricardo, A. C., Xie, H., Navaneethan, S. D., Anderson, A. H., … Chronic Renal Insufficiency Cohort, . (2012). Fibroblast growth factor 23 and Inflammation in CKD. Clin J Am Soc Nephrol, 7(7), 1155–1162. https://doi.org/10.2215/CJN.13281211
Munoz Mendoza, Jair, Tamara Isakova, Ana C. Ricardo, Huiliang Xie, Sankar D. Navaneethan, Amanda H. Anderson, Lydia A. Bazzano, et al. “Fibroblast growth factor 23 and Inflammation in CKD.Clin J Am Soc Nephrol 7, no. 7 (July 2012): 1155–62. https://doi.org/10.2215/CJN.13281211.
Munoz Mendoza J, Isakova T, Ricardo AC, Xie H, Navaneethan SD, Anderson AH, et al. Fibroblast growth factor 23 and Inflammation in CKD. Clin J Am Soc Nephrol. 2012 Jul;7(7):1155–62.
Munoz Mendoza, Jair, et al. “Fibroblast growth factor 23 and Inflammation in CKD.Clin J Am Soc Nephrol, vol. 7, no. 7, July 2012, pp. 1155–62. Pubmed, doi:10.2215/CJN.13281211.
Munoz Mendoza J, Isakova T, Ricardo AC, Xie H, Navaneethan SD, Anderson AH, Bazzano LA, Xie D, Kretzler M, Nessel L, Hamm LL, Negrea L, Leonard MB, Raj D, Wolf M, Chronic Renal Insufficiency Cohort. Fibroblast growth factor 23 and Inflammation in CKD. Clin J Am Soc Nephrol. 2012 Jul;7(7):1155–1162.

Published In

Clin J Am Soc Nephrol

DOI

EISSN

1555-905X

Publication Date

July 2012

Volume

7

Issue

7

Start / End Page

1155 / 1162

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Renal Insufficiency, Chronic
  • Prospective Studies
  • Middle Aged
  • Male
  • Inflammation
  • Humans
  • Fibroblast Growth Factors
  • Fibroblast Growth Factor-23
  • Female