Skip to main content
Journal cover image

Vitamin D deficiency, inflammation, and albuminuria in chronic kidney disease: complex interactions.

Publication ,  Journal Article
Isakova, T; Gutiérrez, OM; Patel, NM; Andress, DL; Wolf, M; Levin, A
Published in: J Ren Nutr
July 2011

OBJECTIVE: Vitamin D may promote cardiovascular health in general population and in chronic kidney disease (CKD) through inhibition of the renin-angiotensin system and anti-inflammatory effects. Although proteinuria is a marker of kidney and cardiovascular disease, few studies have examined vitamin D levels, inflammation, and proteinuria simultaneously in CKD. We evaluated the relationship between calcidiol (25D), calcitriol (1,25D), inflammation, and albuminuria in Study of Early Evaluation of Kidney Disease, a multicenter CKD cohort. DESIGN: A cross-sectional study was carried out. PARTICIPANTS: A total of 1,847 participants were studied, of which 387 were randomly selected for inflammatory biomarker assessment. PREDICTORS AND OUTCOMES: The primary predictors were 25D and 1,25D. The outcome was albuminuria (urine albumin to creatinine ratio [UACR]: >30 mg/g). RESULTS: Albuminuric patients were more likely to have decreased 25D and 1,25D levels and higher interleukin-6 (IL-6) levels compared with normoalbuminuric patients. The lowest tertiles of 25D and 1,25D were associated with 2 to 3 times increased odds of albuminuria compared with the highest tertiles when adjusted for age, gender, race, systolic blood pressure, and diabetes (OR for 25D: 3.0; 95% CI: 1.3 to 7.0; OR for 1,25D: 2.6; 95% CI: 1.7 to 3.9). In analogous linear regression models, 25D and 1,25D were significantly associated with log UACR (P < .0001, for both). In participants for whom inflammatory markers were measured, demographics-adjusted linear regression models that included IL-6 described attenuation of the relationship between 25D, 1,25D, and UACR. CONCLUSIONS: Low 25D and 1,25D levels are independently associated with albuminuria. IL-6 may be an important intermediary between vitamin D deficiency and albuminuria, or vitamin D deficiency may contribute to inflammation and subsequent albuminuria.

Duke Scholars

Published In

J Ren Nutr

DOI

EISSN

1532-8503

Publication Date

July 2011

Volume

21

Issue

4

Start / End Page

295 / 302

Location

United States

Related Subject Headings

  • Vitamin D Deficiency
  • Vitamin D
  • Urology & Nephrology
  • Renin-Angiotensin System
  • Prevalence
  • Multivariate Analysis
  • Middle Aged
  • Male
  • Linear Models
  • Kidney Failure, Chronic
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Isakova, T., Gutiérrez, O. M., Patel, N. M., Andress, D. L., Wolf, M., & Levin, A. (2011). Vitamin D deficiency, inflammation, and albuminuria in chronic kidney disease: complex interactions. J Ren Nutr, 21(4), 295–302. https://doi.org/10.1053/j.jrn.2010.07.002
Isakova, Tamara, Orlando M. Gutiérrez, Neha M. Patel, Dennis L. Andress, Myles Wolf, and Adeera Levin. “Vitamin D deficiency, inflammation, and albuminuria in chronic kidney disease: complex interactions.J Ren Nutr 21, no. 4 (July 2011): 295–302. https://doi.org/10.1053/j.jrn.2010.07.002.
Isakova T, Gutiérrez OM, Patel NM, Andress DL, Wolf M, Levin A. Vitamin D deficiency, inflammation, and albuminuria in chronic kidney disease: complex interactions. J Ren Nutr. 2011 Jul;21(4):295–302.
Isakova, Tamara, et al. “Vitamin D deficiency, inflammation, and albuminuria in chronic kidney disease: complex interactions.J Ren Nutr, vol. 21, no. 4, July 2011, pp. 295–302. Pubmed, doi:10.1053/j.jrn.2010.07.002.
Isakova T, Gutiérrez OM, Patel NM, Andress DL, Wolf M, Levin A. Vitamin D deficiency, inflammation, and albuminuria in chronic kidney disease: complex interactions. J Ren Nutr. 2011 Jul;21(4):295–302.
Journal cover image

Published In

J Ren Nutr

DOI

EISSN

1532-8503

Publication Date

July 2011

Volume

21

Issue

4

Start / End Page

295 / 302

Location

United States

Related Subject Headings

  • Vitamin D Deficiency
  • Vitamin D
  • Urology & Nephrology
  • Renin-Angiotensin System
  • Prevalence
  • Multivariate Analysis
  • Middle Aged
  • Male
  • Linear Models
  • Kidney Failure, Chronic