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The Win Ratio: On Interpretation and Handling of Ties

Publication ,  Journal Article
Dong, G; Hoaglin, DC; Qiu, J; Matsouaka, RA; Chang, YW; Wang, J; Vandemeulebroecke, M
Published in: Statistics in Biopharmaceutical Research
January 2, 2020

To handle composite endpoints, the win ratio has been applied to data analysis and design of clinical trials. Its interpretation, however, is not always clear, and it could handle ties differently. We address these two aspects. First, we express the win ratio as a ratio of two proportions, namely, the proportion of patient-level comparisons in which the experimental treatment “wins” over the control divided by the proportion of “wins” for the control, taking into account the priority order of the components. This equivalent form, the ratio of proportions, can ease communication to clinical trial stakeholders—especially when the win proportions themselves are reported. We recommend such presentations. In some simple cases, we connect the win ratio to the odds ratio, the hazard ratio, the Mann–Whitney U, and the mean difference. In exploring the role of ties, we introduce the win odds, as an extension of the Mann–Whitney odds under the framework of prioritized pairwise comparisons. Finally, we discuss some practical aspects of the win ratio, including rules for defining winners (or losers) and ties, dependence on censoring, win ratio estimands, and benefit-risk assessments, as well as applications to two clinical studies.

Duke Scholars

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Published In

Statistics in Biopharmaceutical Research

DOI

EISSN

1946-6315

Publication Date

January 2, 2020

Volume

12

Issue

1

Start / End Page

99 / 106

Related Subject Headings

  • 4905 Statistics
  • 0104 Statistics
 

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Dong, G., Hoaglin, D. C., Qiu, J., Matsouaka, R. A., Chang, Y. W., Wang, J., & Vandemeulebroecke, M. (2020). The Win Ratio: On Interpretation and Handling of Ties. Statistics in Biopharmaceutical Research, 12(1), 99–106. https://doi.org/10.1080/19466315.2019.1575279
Dong, G., D. C. Hoaglin, J. Qiu, R. A. Matsouaka, Y. W. Chang, J. Wang, and M. Vandemeulebroecke. “The Win Ratio: On Interpretation and Handling of Ties.” Statistics in Biopharmaceutical Research 12, no. 1 (January 2, 2020): 99–106. https://doi.org/10.1080/19466315.2019.1575279.
Dong G, Hoaglin DC, Qiu J, Matsouaka RA, Chang YW, Wang J, et al. The Win Ratio: On Interpretation and Handling of Ties. Statistics in Biopharmaceutical Research. 2020 Jan 2;12(1):99–106.
Dong, G., et al. “The Win Ratio: On Interpretation and Handling of Ties.” Statistics in Biopharmaceutical Research, vol. 12, no. 1, Jan. 2020, pp. 99–106. Scopus, doi:10.1080/19466315.2019.1575279.
Dong G, Hoaglin DC, Qiu J, Matsouaka RA, Chang YW, Wang J, Vandemeulebroecke M. The Win Ratio: On Interpretation and Handling of Ties. Statistics in Biopharmaceutical Research. 2020 Jan 2;12(1):99–106.
Journal cover image

Published In

Statistics in Biopharmaceutical Research

DOI

EISSN

1946-6315

Publication Date

January 2, 2020

Volume

12

Issue

1

Start / End Page

99 / 106

Related Subject Headings

  • 4905 Statistics
  • 0104 Statistics