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The genetic component of the forced diving bradycardia response in mammals.

Publication ,  Journal Article
Fahlman, A; Bostrom, BL; Dillon, KH; Jones, DR
Published in: Frontiers in physiology
January 2011

We contrasted the forced diving bradycardia between two genetically similar (inbred) rat strains (Fischer and Buffalo), compared to that of outbred rats (Wistar). The animals were habituated to forced diving for 4 weeks. Each animal was then tested during one 40 s dive on each of 3 days. The heart rate (f(H)) was measured before, during, and after each dive. Fischer and Buffalo exhibited marked difference in dive bradycardia (Fischer: 120.9 ± 14.0 beats min(-1) vs. Buffalo: 92.8 ± 12.8 beats min(-1), P < 0.05). Outbred rats showed an intermediate response (103.0 ± 30.9 beats min(-1)) but their between-animal variability in mean dive f(H) and pre-diving resting f(H) were higher than the inbred strains (P < 0.05), which showed no difference (P > 0.05). The decreased variability in f(H) in inbred rats as compared with the outbred group indicates that reduced genetic variability minimizes variability of the diving bradycardia between individuals. Heritability within strains was assessed by the repeatability (R) index and was 0.93 ± 0.05 for the outbred, 0.84 ± 0.16 for Buffalo, and 0.80 ± 0.12 for Fischer rats for f(H) during diving. Our results suggest that a portion of the mammalian diving bradycardia may be a heritable trait.

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Published In

Frontiers in physiology

DOI

EISSN

1664-042X

ISSN

1664-042X

Publication Date

January 2011

Volume

2

Start / End Page

63

Related Subject Headings

  • 3208 Medical physiology
  • 3101 Biochemistry and cell biology
  • 1701 Psychology
  • 1116 Medical Physiology
  • 0606 Physiology
 

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Fahlman, A., Bostrom, B. L., Dillon, K. H., & Jones, D. R. (2011). The genetic component of the forced diving bradycardia response in mammals. Frontiers in Physiology, 2, 63. https://doi.org/10.3389/fphys.2011.00063
Fahlman, Andreas, Brian L. Bostrom, Kiran H. Dillon, and David R. Jones. “The genetic component of the forced diving bradycardia response in mammals.Frontiers in Physiology 2 (January 2011): 63. https://doi.org/10.3389/fphys.2011.00063.
Fahlman A, Bostrom BL, Dillon KH, Jones DR. The genetic component of the forced diving bradycardia response in mammals. Frontiers in physiology. 2011 Jan;2:63.
Fahlman, Andreas, et al. “The genetic component of the forced diving bradycardia response in mammals.Frontiers in Physiology, vol. 2, Jan. 2011, p. 63. Epmc, doi:10.3389/fphys.2011.00063.
Fahlman A, Bostrom BL, Dillon KH, Jones DR. The genetic component of the forced diving bradycardia response in mammals. Frontiers in physiology. 2011 Jan;2:63.

Published In

Frontiers in physiology

DOI

EISSN

1664-042X

ISSN

1664-042X

Publication Date

January 2011

Volume

2

Start / End Page

63

Related Subject Headings

  • 3208 Medical physiology
  • 3101 Biochemistry and cell biology
  • 1701 Psychology
  • 1116 Medical Physiology
  • 0606 Physiology