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On the likelihood of decompression sickness during H(2) biochemical decompression in pigs.

Publication ,  Journal Article
Fahlman, A; Tikuisis, P; Himm, JF; Weathersby, PK; Kayar, SR
Published in: Journal of applied physiology (Bethesda, Md. : 1985)
December 2001

A probabilistic model was used to predict decompression sickness (DCS) outcome in pigs during exposures to hyperbaric H(2) to quantify the effects of H(2) biochemical decompression, a process in which metabolism of H(2) by intestinal microbes facilitates decompression. The data set included 109 exposures to 22-26 atm, ca. 88% H(2), 9% He, 2% O(2), 1% N(2), for 0.5-24 h. Single exponential kinetics described the tissue partial pressures (Ptis) of H(2) and He at time t: Ptis = integral (Pamb - Ptis). tau(-1) dt, where Pamb is ambient pressure and tau is a time constant. The probability of DCS [P(DCS)] was predicted from the risk function: P(DCS) = 1 - e(-r), where r = integral (Ptis(H(2)) + Ptis(He) - Thr - Pamb). Pamb(-1) dt, and Thr is a threshold parameter. Inclusion of a parameter (A) to estimate the effect of H(2) metabolism on P(DCS): Ptis(H(2)) = integral (Pamb - A - Ptis(H(2))). tau(-1) dt, significantly improved the prediction of P(DCS). Thus lower P(DCS) was predicted by microbial H(2) metabolism during H(2) biochemical decompression.

Duke Scholars

Published In

Journal of applied physiology (Bethesda, Md. : 1985)

DOI

EISSN

1522-1601

ISSN

8750-7587

Publication Date

December 2001

Volume

91

Issue

6

Start / End Page

2720 / 2729

Related Subject Headings

  • Swine
  • Physiology
  • Models, Theoretical
  • Methanobacteriaceae
  • Likelihood Functions
  • Intestines
  • Incidence
  • Hydrogen
  • Forecasting
  • Decompression Sickness
 

Citation

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Fahlman, A., Tikuisis, P., Himm, J. F., Weathersby, P. K., & Kayar, S. R. (2001). On the likelihood of decompression sickness during H(2) biochemical decompression in pigs. Journal of Applied Physiology (Bethesda, Md. : 1985), 91(6), 2720–2729. https://doi.org/10.1152/jappl.2001.91.6.2720
Fahlman, A., P. Tikuisis, J. F. Himm, P. K. Weathersby, and S. R. Kayar. “On the likelihood of decompression sickness during H(2) biochemical decompression in pigs.Journal of Applied Physiology (Bethesda, Md. : 1985) 91, no. 6 (December 2001): 2720–29. https://doi.org/10.1152/jappl.2001.91.6.2720.
Fahlman A, Tikuisis P, Himm JF, Weathersby PK, Kayar SR. On the likelihood of decompression sickness during H(2) biochemical decompression in pigs. Journal of applied physiology (Bethesda, Md : 1985). 2001 Dec;91(6):2720–9.
Fahlman, A., et al. “On the likelihood of decompression sickness during H(2) biochemical decompression in pigs.Journal of Applied Physiology (Bethesda, Md. : 1985), vol. 91, no. 6, Dec. 2001, pp. 2720–29. Epmc, doi:10.1152/jappl.2001.91.6.2720.
Fahlman A, Tikuisis P, Himm JF, Weathersby PK, Kayar SR. On the likelihood of decompression sickness during H(2) biochemical decompression in pigs. Journal of applied physiology (Bethesda, Md : 1985). 2001 Dec;91(6):2720–2729.

Published In

Journal of applied physiology (Bethesda, Md. : 1985)

DOI

EISSN

1522-1601

ISSN

8750-7587

Publication Date

December 2001

Volume

91

Issue

6

Start / End Page

2720 / 2729

Related Subject Headings

  • Swine
  • Physiology
  • Models, Theoretical
  • Methanobacteriaceae
  • Likelihood Functions
  • Intestines
  • Incidence
  • Hydrogen
  • Forecasting
  • Decompression Sickness