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Prevalence, Incidence, and Risk Factors for Overall, Physical, and Cognitive Independence Among Those From Exceptionally Long-Lived Families: The Long Life Family Study.

Publication ,  Journal Article
Santanasto, AJ; Marron, MM; Boudreau, RM; Feitosa, MF; Wojczynski, MK; Arbeev, KG; Thyagarajan, B; Schupf, N; Stallard, E; Sebastiani, P ...
Published in: The journals of gerontology. Series A, Biological sciences and medical sciences
April 2020

The Long Life Family Study (LLFS) enrolled families exhibiting exceptional longevity. The goal of this article was to determine the prevalence and predictors of remaining independent after 7 years in the oldest generation.We examined 7-year change in physical (free of activities of daily living difficulty), cognitive (Mini-Mental State Examination score ≥ 24), and overall independence (physically/cognitively independent) in adults aged 90.3 ± 6.3 from LLFS's oldest generation. Potential predictors (n = 28) of remaining independent included demographics, diseases, biomarkers, anthropometrics, and physical and cognitive performance tasks and were determined using generalized estimating equations (α: p < .05). This was a discovery/exploratory analysis, so no multiple testing correction was employed and the results require independent replication.At baseline (n = 1442), 67.3%, 83.8%, and 79.7% were overall, physically, and cognitively independent, respectively. After 7 years, 66% died, 7.5% were lost to follow-up, and the prevalence of overall independence decreased to 59.1% in survivors (-8.2%, 95% confidence interval: -14.1%, 2.2%). Of those with baseline independence, 156/226 (69.0%) remained independent. Predictors of remaining physically independent included younger age, better Short Physical Performance Battery score and lung function, smaller waist circumference, and lower soluble receptor for advanced glycation end-product levels (p < .05). Predictors of remaining cognitively independent included no cancer history, better Digit Symbol Substitution Test performance, and higher body weight (p < .05).The prevalence of independence decreased by only 8.2% after 7 years, demonstrating the close correspondence between disability and mortality. Further, despite a mean baseline age of 90 years, a large proportion of survivors remained independent, suggesting this exceptional subgroup may harbor protective mechanisms.

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Published In

The journals of gerontology. Series A, Biological sciences and medical sciences

DOI

EISSN

1758-535X

ISSN

1079-5006

Publication Date

April 2020

Volume

75

Issue

5

Start / End Page

899 / 905

Related Subject Headings

  • Risk Factors
  • Prevalence
  • Male
  • Longevity
  • Incidence
  • Humans
  • Gerontology
  • Female
  • Disabled Persons
  • Cognition
 

Citation

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Santanasto, A. J., Marron, M. M., Boudreau, R. M., Feitosa, M. F., Wojczynski, M. K., Arbeev, K. G., … Newman, A. B. (2020). Prevalence, Incidence, and Risk Factors for Overall, Physical, and Cognitive Independence Among Those From Exceptionally Long-Lived Families: The Long Life Family Study. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 75(5), 899–905. https://doi.org/10.1093/gerona/glz124
Santanasto, Adam J., Megan M. Marron, Robert M. Boudreau, Mary F. Feitosa, Mary K. Wojczynski, Konstantin G. Arbeev, Bharat Thyagarajan, et al. “Prevalence, Incidence, and Risk Factors for Overall, Physical, and Cognitive Independence Among Those From Exceptionally Long-Lived Families: The Long Life Family Study.The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 75, no. 5 (April 2020): 899–905. https://doi.org/10.1093/gerona/glz124.
Santanasto AJ, Marron MM, Boudreau RM, Feitosa MF, Wojczynski MK, Arbeev KG, et al. Prevalence, Incidence, and Risk Factors for Overall, Physical, and Cognitive Independence Among Those From Exceptionally Long-Lived Families: The Long Life Family Study. The journals of gerontology Series A, Biological sciences and medical sciences. 2020 Apr;75(5):899–905.
Santanasto, Adam J., et al. “Prevalence, Incidence, and Risk Factors for Overall, Physical, and Cognitive Independence Among Those From Exceptionally Long-Lived Families: The Long Life Family Study.The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, vol. 75, no. 5, Apr. 2020, pp. 899–905. Epmc, doi:10.1093/gerona/glz124.
Santanasto AJ, Marron MM, Boudreau RM, Feitosa MF, Wojczynski MK, Arbeev KG, Thyagarajan B, Schupf N, Stallard E, Sebastiani P, Cosentino S, Christensen K, Newman AB. Prevalence, Incidence, and Risk Factors for Overall, Physical, and Cognitive Independence Among Those From Exceptionally Long-Lived Families: The Long Life Family Study. The journals of gerontology Series A, Biological sciences and medical sciences. 2020 Apr;75(5):899–905.
Journal cover image

Published In

The journals of gerontology. Series A, Biological sciences and medical sciences

DOI

EISSN

1758-535X

ISSN

1079-5006

Publication Date

April 2020

Volume

75

Issue

5

Start / End Page

899 / 905

Related Subject Headings

  • Risk Factors
  • Prevalence
  • Male
  • Longevity
  • Incidence
  • Humans
  • Gerontology
  • Female
  • Disabled Persons
  • Cognition