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A new predictive model for an improved respiratory isolation strategy in HIV-infected patients with PTB.

Publication ,  Journal Article
Carugati, M; Schiroli, C; Zanini, F; Vanoni, N; Galli, M; Adorni, F; Franzetti, F
Published in: Int J Tuberc Lung Dis
July 2014

SETTING: Luigi Sacco Hospital, Milan, Italy, 1 January 2000-31 December 2010. OBJECTIVES: To develop a predictive score for identifying human immunodeficiency virus (HIV) infected patients with pulmonary tuberculosis (PTB). DESIGN: Retrospective study based on the medical charts of HIV-infected patients admitted consecutively on presumption of PTB. Patients with culture-positive TB were included in the TB group. Culture-negative subjects formed the non-TB group. Risk factors for PTB were identified and a predictive model was developed. The diagnostic test accuracy of the derived score and that of previously developed scores were analysed. RESULTS: A total of 65 patients were included in the TB group and 505 subjects in the non-TB group. An eight-variable model (age, origin, alcohol use, respiratory rate, weight loss, haemoglobin, white blood cell count, typical chest X-ray) was derived. When compared with the different scores, this model showed the greatest area under the receiver operating characteristic curve (0.880). This score was the only one to present a negative likelihood ratio of <0.2, which is the threshold for giving strong diagnostic evidence against TB. CONCLUSIONS: This model may be useful in predicting PTB in HIV patients in low-endemic countries. A validation study is necessary.

Duke Scholars

Published In

Int J Tuberc Lung Dis

DOI

EISSN

1815-7920

Publication Date

July 2014

Volume

18

Issue

7

Start / End Page

831 / 836

Location

France

Related Subject Headings

  • Tuberculosis, Pulmonary
  • Risk Factors
  • Retrospective Studies
  • ROC Curve
  • Predictive Value of Tests
  • Models, Statistical
  • Microbiology
  • Male
  • Likelihood Functions
  • Italy
 

Citation

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ICMJE
MLA
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Carugati, M., Schiroli, C., Zanini, F., Vanoni, N., Galli, M., Adorni, F., & Franzetti, F. (2014). A new predictive model for an improved respiratory isolation strategy in HIV-infected patients with PTB. Int J Tuberc Lung Dis, 18(7), 831–836. https://doi.org/10.5588/ijtld.13.0588
Carugati, M., C. Schiroli, F. Zanini, N. Vanoni, M. Galli, F. Adorni, and F. Franzetti. “A new predictive model for an improved respiratory isolation strategy in HIV-infected patients with PTB.Int J Tuberc Lung Dis 18, no. 7 (July 2014): 831–36. https://doi.org/10.5588/ijtld.13.0588.
Carugati M, Schiroli C, Zanini F, Vanoni N, Galli M, Adorni F, et al. A new predictive model for an improved respiratory isolation strategy in HIV-infected patients with PTB. Int J Tuberc Lung Dis. 2014 Jul;18(7):831–6.
Carugati, M., et al. “A new predictive model for an improved respiratory isolation strategy in HIV-infected patients with PTB.Int J Tuberc Lung Dis, vol. 18, no. 7, July 2014, pp. 831–36. Pubmed, doi:10.5588/ijtld.13.0588.
Carugati M, Schiroli C, Zanini F, Vanoni N, Galli M, Adorni F, Franzetti F. A new predictive model for an improved respiratory isolation strategy in HIV-infected patients with PTB. Int J Tuberc Lung Dis. 2014 Jul;18(7):831–836.

Published In

Int J Tuberc Lung Dis

DOI

EISSN

1815-7920

Publication Date

July 2014

Volume

18

Issue

7

Start / End Page

831 / 836

Location

France

Related Subject Headings

  • Tuberculosis, Pulmonary
  • Risk Factors
  • Retrospective Studies
  • ROC Curve
  • Predictive Value of Tests
  • Models, Statistical
  • Microbiology
  • Male
  • Likelihood Functions
  • Italy