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Vitamin D Supplementation and Prevention of Type 2 Diabetes.

Publication ,  Journal Article
Pittas, AG; Dawson-Hughes, B; Sheehan, P; Ware, JH; Knowler, WC; Aroda, VR; Brodsky, I; Ceglia, L; Chadha, C; Chatterjee, R; Desouza, C ...
Published in: N Engl J Med
August 8, 2019

BACKGROUND: Observational studies support an association between a low blood 25-hydroxyvitamin D level and the risk of type 2 diabetes. However, whether vitamin D supplementation lowers the risk of diabetes is unknown. METHODS: We randomly assigned adults who met at least two of three glycemic criteria for prediabetes (fasting plasma glucose level, 100 to 125 mg per deciliter; plasma glucose level 2 hours after a 75-g oral glucose load, 140 to 199 mg per deciliter; and glycated hemoglobin level, 5.7 to 6.4%) and no diagnostic criteria for diabetes to receive 4000 IU per day of vitamin D3 or placebo, regardless of the baseline serum 25-hydroxyvitamin D level. The primary outcome in this time-to-event analysis was new-onset diabetes, and the trial design was event-driven, with a target number of diabetes events of 508. RESULTS: A total of 2423 participants underwent randomization (1211 to the vitamin D group and 1212 to the placebo group). By month 24, the mean serum 25-hydroxyvitamin D level in the vitamin D group was 54.3 ng per milliliter (from 27.7 ng per milliliter at baseline), as compared with 28.8 ng per milliliter in the placebo group (from 28.2 ng per milliliter at baseline). After a median follow-up of 2.5 years, the primary outcome of diabetes occurred in 293 participants in the vitamin D group and 323 in the placebo group (9.39 and 10.66 events per 100 person-years, respectively). The hazard ratio for vitamin D as compared with placebo was 0.88 (95% confidence interval, 0.75 to 1.04; P = 0.12). The incidence of adverse events did not differ significantly between the two groups. CONCLUSIONS: Among persons at high risk for type 2 diabetes not selected for vitamin D insufficiency, vitamin D3 supplementation at a dose of 4000 IU per day did not result in a significantly lower risk of diabetes than placebo. (Funded by the National Institute of Diabetes and Digestive and Kidney Diseases and others; D2d ClinicalTrials.gov number, NCT01942694.).

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Published In

N Engl J Med

DOI

EISSN

1533-4406

Publication Date

August 8, 2019

Volume

381

Issue

6

Start / End Page

520 / 530

Location

United States

Related Subject Headings

  • Vitamins
  • Vitamin D
  • Treatment Failure
  • Risk Factors
  • Prediabetic State
  • Middle Aged
  • Male
  • Kaplan-Meier Estimate
  • Humans
  • General & Internal Medicine
 

Citation

APA
Chicago
ICMJE
MLA
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Pittas, A. G., Dawson-Hughes, B., Sheehan, P., Ware, J. H., Knowler, W. C., Aroda, V. R., … D2d Research Group, . (2019). Vitamin D Supplementation and Prevention of Type 2 Diabetes. N Engl J Med, 381(6), 520–530. https://doi.org/10.1056/NEJMoa1900906
Pittas, Anastassios G., Bess Dawson-Hughes, Patricia Sheehan, James H. Ware, William C. Knowler, Vanita R. Aroda, Irwin Brodsky, et al. “Vitamin D Supplementation and Prevention of Type 2 Diabetes.N Engl J Med 381, no. 6 (August 8, 2019): 520–30. https://doi.org/10.1056/NEJMoa1900906.
Pittas AG, Dawson-Hughes B, Sheehan P, Ware JH, Knowler WC, Aroda VR, et al. Vitamin D Supplementation and Prevention of Type 2 Diabetes. N Engl J Med. 2019 Aug 8;381(6):520–30.
Pittas, Anastassios G., et al. “Vitamin D Supplementation and Prevention of Type 2 Diabetes.N Engl J Med, vol. 381, no. 6, Aug. 2019, pp. 520–30. Pubmed, doi:10.1056/NEJMoa1900906.
Pittas AG, Dawson-Hughes B, Sheehan P, Ware JH, Knowler WC, Aroda VR, Brodsky I, Ceglia L, Chadha C, Chatterjee R, Desouza C, Dolor R, Foreyt J, Fuss P, Ghazi A, Hsia DS, Johnson KC, Kashyap SR, Kim S, LeBlanc ES, Lewis MR, Liao E, Neff LM, Nelson J, O’Neil P, Park J, Peters A, Phillips LS, Pratley R, Raskin P, Rasouli N, Robbins D, Rosen C, Vickery EM, Staten M, D2d Research Group. Vitamin D Supplementation and Prevention of Type 2 Diabetes. N Engl J Med. 2019 Aug 8;381(6):520–530.

Published In

N Engl J Med

DOI

EISSN

1533-4406

Publication Date

August 8, 2019

Volume

381

Issue

6

Start / End Page

520 / 530

Location

United States

Related Subject Headings

  • Vitamins
  • Vitamin D
  • Treatment Failure
  • Risk Factors
  • Prediabetic State
  • Middle Aged
  • Male
  • Kaplan-Meier Estimate
  • Humans
  • General & Internal Medicine